{"id":"W2076446882","doi":"10.1002/stem.563","title":"Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis","year":2010,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":471,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"China Scholarship Council","keywords":"Biology; Aldehyde dehydrogenase; Metastasis; Gene isoform; Stem cell; Breast cancer; Cancer research; Cancer stem cell; Lactate dehydrogenase; Cancer; Cell biology; Genetics; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002343848,0.0002113333,0.0002544614,0.0006571468,0.0001724143,0.0003398423,0.00008450677,0.0001260682,0.001465907],"category_scores_gemma":[0.0003945175,0.0001001443,0.0001673466,0.0005614554,0.0002174013,0.000153969,0.0001215593,0.0002937283,0.0002984813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003320882,"about_ca_system_score_gemma":0.0001795793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009398512,"about_ca_topic_score_gemma":0.001296837,"domain_scores_codex":[0.9998699,0.00001867599,0.000009530925,0.00002908816,0.00005731314,0.00001543463],"domain_scores_gemma":[0.9996853,0.0000625451,0.0001148706,0.00001937111,0.00007419003,0.00004373415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004565627,0.0000663827,0.1424069,0.0001112518,0.00008773354,0.000200287,0.00008381067,0.0003278707,0.8256233,0.0003356922,0.0003616582,0.02993858],"study_design_scores_gemma":[0.00001572222,0.0004388817,0.5381085,0.00001124824,0.000094961,0.002324739,0.0001125972,0.001923877,0.4514439,0.000649797,0.004860053,0.000015696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916537,0.002550734,0.003557529,0.0001290866,0.00001349154,0.00002092302,0.0007575605,0.00008877637,0.001228189],"genre_scores_gemma":[0.9965199,0.0008964128,0.0009982096,0.00002482152,0.000009747057,0.00001003623,0.0006551114,0.000006873573,0.0008789934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465907,"threshold_uncertainty_score":0.004903972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527762349031583,"score_gpt":0.2638023808323873,"score_spread":0.2485247573420715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}