{"id":"W2076446882","doi":"10.1002/stem.563","title":"Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis","year":2010,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":471,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"China Scholarship Council","keywords":"Biology; Aldehyde dehydrogenase; Metastasis; Gene isoform; Stem cell; Breast cancer; Cancer research; Cancer stem cell; Lactate dehydrogenase; Cancer; Cell biology; Genetics; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003749298,0.0004030267,0.001069389,0.0002295203,0.00008077516,0.00001786044,0.000199919,0.0002147155,0.0008600925],"category_scores_gemma":[0.000003634463,0.0003319434,0.0002726197,0.0003753875,0.000141232,0.0002140761,0.0002289984,0.0003542357,0.00002169822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103071,"about_ca_system_score_gemma":0.0003268271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755891,"about_ca_topic_score_gemma":0.0001324286,"domain_scores_codex":[0.9975144,0.00006637061,0.0005789815,0.000684058,0.0006660867,0.0004901115],"domain_scores_gemma":[0.9978397,0.0001017638,0.0004523828,0.0006856716,0.0003755788,0.0005448905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023213,0.0003434511,0.0003562913,0.0009440715,0.0003016713,0.00001799329,0.001837087,0.000009605322,0.9493436,0.000006033034,0.003658487,0.04215848],"study_design_scores_gemma":[0.001617204,0.0003683044,0.001443718,0.0003626744,0.0006002373,0.00004289859,0.0003201093,0.00009732445,0.9868612,0.000005624771,0.008007823,0.0002728292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915334,0.0009951972,0.0001723692,0.0005219321,0.0005457953,0.001263015,0.004189617,0.00003389381,0.0007447552],"genre_scores_gemma":[0.9966445,0.0005339651,0.0006647293,0.0004140257,0.0001439441,0.00007499904,0.000004550244,0.00006362188,0.001455675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04188565,"threshold_uncertainty_score":0.9999133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527762349031583,"score_gpt":0.2638023808323873,"score_spread":0.2485247573420715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}