{"id":"W2076454494","doi":"10.1021/acs.joc.5b00405","title":"Aggregation of a Tetrasaccharide Acceptor Observed by NMR: Synthesis of Pentasaccharide Fragments of the Le<sup>a</sup>Le<sup>x</sup> Tumor-Associated Hexasaccharide Antigen","year":2015,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Tetrasaccharide; Stereochemistry; Disaccharide; Acceptor; Glycoside; Carbon-13 NMR; Trisaccharide; Nuclear magnetic resonance spectroscopy; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009466,0.0002313615,0.0001370535,0.00007169681,0.00008073803,0.0001637577,0.0001124022,0.0001744944,0.000510905],"category_scores_gemma":[0.0001050008,0.00009197959,0.0001325315,0.0001082837,0.0001074337,0.0001705985,0.0001460417,0.0003685217,0.0002511576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238161,"about_ca_system_score_gemma":0.0000836485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002875172,"about_ca_topic_score_gemma":0.0002625568,"domain_scores_codex":[0.9999125,0.00001990835,0.000006381931,0.00002306486,0.00001982915,0.00001832882],"domain_scores_gemma":[0.9998981,0.00001666546,0.00003125351,0.00001226065,0.000019385,0.0000223198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003050482,0.000006304627,0.00004934112,0.0000049441,0.00000152467,0.00001590933,0.000008435283,0.00002940555,0.999514,0.00001636393,0.00000660352,0.0003166603],"study_design_scores_gemma":[0.000002468864,0.0001100269,0.0005974839,7.245098e-7,0.000003320325,0.00005444949,0.000006605334,0.0004577068,0.998447,0.00001001328,0.0003082404,0.000001926112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946198,0.0002232192,0.004476997,0.00002815145,0.000008228933,0.00001552915,0.00006660871,0.00002332851,0.0005380387],"genre_scores_gemma":[0.9934033,0.0001618737,0.004985578,0.00004124534,0.000004975193,0.0000164027,0.0002464452,0.00001766598,0.001122528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000510905,"threshold_uncertainty_score":0.001709163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900881930234702,"score_gpt":0.2398279085421879,"score_spread":0.2208190892398409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}