{"id":"W2076500219","doi":"10.1016/j.jip.2004.02.002","title":"The Bacillus thuringiensis Cry1Aa toxin: effects of trypsin and chymotrypsin site mutations on toxicity and stability","year":2004,"lang":"en","type":"article","venue":"Journal of Invertebrate Pathology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Forest Service; Biotechnology Research Institute","funders":"Natural Resources Canada; Canadian Natural Resources Limited","keywords":"Bacillus thuringiensis; Biology; Microbiology; Toxin; Trypsin; Bacillales; Protease; Spruce budworm; Escherichia coli; Choristoneura fumiferana; Proteases; Mutant; Chymotrypsin; Biochemistry; Enzyme; Bacteria; PEST analysis; Botany; Bacillus subtilis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003139891,0.0001231905,0.0002106538,0.0000453831,0.0001223257,0.00001736844,0.00009494551,0.0001338274,0.00000186648],"category_scores_gemma":[0.0003021057,0.00008599178,0.00006137303,0.00006686226,0.0003355077,0.000005863255,0.00005409398,0.0001449707,8.827498e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001747884,"about_ca_system_score_gemma":0.00009173879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000506364,"about_ca_topic_score_gemma":0.0001485337,"domain_scores_codex":[0.9990976,0.00013948,0.0003205792,0.0001603485,0.0001104655,0.0001714626],"domain_scores_gemma":[0.999252,0.00006971251,0.0002436401,0.0001945602,0.0001681986,0.00007191614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00020845,0.0001019242,0.00326455,0.00005208763,0.00004445653,0.0000477056,0.0003352789,0.00006379435,0.9937333,0.0002478642,0.00007460713,0.001825938],"study_design_scores_gemma":[0.001471737,0.002032226,0.03160411,0.00003828817,0.00004129319,0.0003086756,0.0001484093,0.00002032257,0.9618773,0.00207421,0.0002692264,0.0001141469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966378,0.002191861,0.0004274703,0.0003914434,0.0001616552,0.0001022321,0.000009101296,0.000001853099,0.00007664037],"genre_scores_gemma":[0.9976014,0.001202711,0.0007519072,0.0003393717,0.00007215612,0.000002061123,0.000002597441,0.000008893967,0.0000188365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03185599,"threshold_uncertainty_score":0.3506643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006386026595990306,"score_gpt":0.2188652569379698,"score_spread":0.2124792303419795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}