{"id":"W2076528751","doi":"10.1002/1521-4141(200001)30:1<227::aid-immu227>3.0.co;2-x","title":"Identification of a novel mechanism for endotoxin-mediated down-modulation of CC chemokine receptor expression","year":2000,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre; Robarts Clinical Trials","funders":"Medical Research Council; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"CCR2; Chemokine receptor; Biology; CCR1; Tyrosine kinase; Molecular biology; Cell biology; Tropomyosin receptor kinase C; Chemokine; Receptor; Biochemistry; Platelet-derived growth factor receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008098798,0.0001173138,0.0004220601,0.0001932984,0.00003154156,0.000004606857,0.000142929,0.00005900718,0.0003243417],"category_scores_gemma":[0.0003948858,0.00009608502,0.0001901387,0.0001447614,0.00006325735,0.0000850342,0.0000189523,0.0001788581,0.000008497304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003665565,"about_ca_system_score_gemma":0.00004863677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001515851,"about_ca_topic_score_gemma":5.776342e-8,"domain_scores_codex":[0.9983215,0.0001085658,0.001114991,0.0001253531,0.0001910347,0.0001385093],"domain_scores_gemma":[0.9980782,0.0001043044,0.001013099,0.0001898089,0.0005660274,0.00004860431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001025978,0.0007464889,0.00004293883,0.00005697023,0.0001075667,0.000003224581,0.0003273529,0.0000165982,0.9857448,0.00007894474,0.0001574042,0.01169173],"study_design_scores_gemma":[0.01050125,0.0008703056,0.001592338,0.0003115425,0.00007388617,0.0001292449,0.00009840544,0.0004243003,0.9842837,0.00004060603,0.00159868,0.00007571373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795753,0.0002511097,0.01912368,0.0002825848,0.0002579698,0.000212356,0.00001795852,0.00001011771,0.0002688835],"genre_scores_gemma":[0.9932533,0.0002641367,0.005886777,0.00003279133,0.0002105155,0.000001687401,0.00003704059,0.00003024217,0.0002835238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01367794,"threshold_uncertainty_score":0.3918233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612714546469533,"score_gpt":0.2507546015066058,"score_spread":0.2346274560419105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}