{"id":"W2076557803","doi":"10.1182/blood-2003-06-2099","title":"Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Progenitor cell; Haematopoiesis; Bone marrow; Complement system; iC3b; Anaphylatoxin; Granulocyte colony-stimulating factor; Mobilization; Stromal cell; Stem cell; Homing (biology); Immunology; Cell biology; Biology; Chemistry; Cancer research; Internal medicine; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000296753,0.001313864,0.0004789944,0.001074933,0.0004448177,0.0005050901,0.0005234702,0.00104915,0.001814281],"category_scores_gemma":[0.0001509953,0.0003326062,0.0006285069,0.0003365751,0.0009985946,0.000444698,0.0005182612,0.001537697,0.0006677305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006949771,"about_ca_system_score_gemma":0.0005467096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001347718,"about_ca_topic_score_gemma":0.00195209,"domain_scores_codex":[0.9997104,0.00004137766,0.00002767488,0.00007127687,0.00007861038,0.0000705838],"domain_scores_gemma":[0.9997147,0.00003889246,0.0001202483,0.00003296608,0.00001802634,0.00007523541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249305,0.00002247556,0.0001084659,0.00002532568,0.000004286002,0.00007099823,0.00001183024,0.00002724776,0.9988419,0.000211593,0.00002772678,0.0005232703],"study_design_scores_gemma":[0.00004628126,0.000488358,0.004352021,0.00002028948,0.00003474173,0.0008647116,0.00002956435,0.0005359575,0.9919024,0.0002076747,0.0015043,0.00001380683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867913,0.002423478,0.007446584,0.0004024359,0.00003541606,0.0001052023,0.001081035,0.0002586701,0.001455977],"genre_scores_gemma":[0.985857,0.001990114,0.007579161,0.0002336274,0.00002632558,0.0001375602,0.0009168254,0.00008408741,0.003175244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001814281,"threshold_uncertainty_score":0.006069362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0534705643872653,"score_gpt":0.2913751801326894,"score_spread":0.2379046157454241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}