{"id":"W2076557803","doi":"10.1182/blood-2003-06-2099","title":"Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Progenitor cell; Haematopoiesis; Bone marrow; Complement system; iC3b; Anaphylatoxin; Granulocyte colony-stimulating factor; Mobilization; Stromal cell; Stem cell; Homing (biology); Immunology; Cell biology; Biology; Chemistry; Cancer research; Internal medicine; Medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007743247,0.0001793381,0.0004772559,0.0003348314,0.00003029097,0.00000504706,0.0001255158,0.0001038412,0.0001091097],"category_scores_gemma":[0.0001050072,0.0001676855,0.00006462662,0.0003836059,0.00005910734,0.00005065963,0.00006003317,0.00009109142,0.000013307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001517009,"about_ca_system_score_gemma":0.00006855904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001334577,"about_ca_topic_score_gemma":0.002403213,"domain_scores_codex":[0.9979312,0.0003413762,0.0009539036,0.0003602707,0.00006369726,0.0003495403],"domain_scores_gemma":[0.9992809,0.0001716022,0.0002454051,0.0002095424,0.00007888077,0.00001365729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003855304,0.003649462,0.09814844,0.000688198,0.0000732152,0.000003614431,0.002359623,0.00009062773,0.8938681,0.0003854678,0.0002633061,0.00008445088],"study_design_scores_gemma":[0.02952332,0.0009302786,0.02025334,0.002117543,0.0001375734,0.00002988031,0.03037988,0.00004286756,0.9138145,0.0002547386,0.001926741,0.0005893229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921943,0.005149819,0.00003384984,0.00002681197,0.0002520506,0.002149833,0.0001504391,0.00001275503,0.00003016848],"genre_scores_gemma":[0.998493,0.00004386061,0.0004596661,0.00001535965,0.000006840124,0.0006897499,0.00006882735,0.00001888916,0.0002037668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0778951,"threshold_uncertainty_score":0.6838015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0534705643872653,"score_gpt":0.2913751801326894,"score_spread":0.2379046157454241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}