{"id":"W2076596744","doi":"10.1182/blood-2006-08-044370","title":"TC-PTP–deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Bone marrow; Stromal cell; Lymphopoiesis; Biology; Cancer research; Cytokine; Tyrosine phosphorylation; Protein tyrosine phosphatase; Cell biology; Chemistry; Signal transduction; Immunology; Internal medicine; Haematopoiesis; Stem cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000402755,0.0002234007,0.0002387103,0.000112323,0.00005568446,0.00002224215,0.0002879377,0.0001430281,0.0001226991],"category_scores_gemma":[0.00006755808,0.0002339195,0.0001124234,0.0001775355,0.00005353815,0.000008382145,0.0003729928,0.00006300712,0.00007531979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002496614,"about_ca_system_score_gemma":0.00008758742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001134224,"about_ca_topic_score_gemma":0.0001193167,"domain_scores_codex":[0.998364,0.00002913553,0.0004227707,0.0004199545,0.0002613276,0.0005027885],"domain_scores_gemma":[0.9990189,0.00001171511,0.0001124239,0.0004763528,0.0001271529,0.0002534547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004958517,0.0002890077,0.001194813,0.00003997697,0.00004277878,0.00004929374,0.00008698496,0.00006515458,0.9940044,0.00007650156,0.002223252,0.00143204],"study_design_scores_gemma":[0.0009840067,0.002300697,0.003496407,0.0000237085,0.0000459991,0.00008663451,0.0001005282,0.000003306544,0.9881591,0.000003339334,0.004535504,0.0002608084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918944,0.0006199618,0.006031221,0.0000760938,0.0002046447,0.0003887693,0.0002686871,0.00001997869,0.0004963067],"genre_scores_gemma":[0.9956245,0.000009690204,0.003270895,0.0003076937,0.0001862103,0.00002987317,0.000263712,0.00003090031,0.0002765276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005845285,"threshold_uncertainty_score":0.953896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005761424982093795,"score_gpt":0.221755963509468,"score_spread":0.2159945385273742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}