{"id":"W2076626325","doi":"10.1016/j.bpj.2008.12.2433","title":"Lidocaine Inhibition of HCN1 Channels is Fast, Voltage-dependent and Reversible","year":2009,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lidocaine; Chinese hamster ovary cell; Chemistry; Patch clamp; Hyperpolarization (physics); Biophysics; Electrophysiology; Pharmacology; Internal medicine; Anesthesia; Biology; Biochemistry; Stereochemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003332581,0.0003562778,0.0005282324,0.0001394446,0.0002304959,0.0005359476,0.0004876317,0.0003465092,0.00373759],"category_scores_gemma":[0.0007076656,0.0003000534,0.0004111136,0.0001135535,0.0004092246,0.0004993387,0.0003158694,0.000804818,0.0007491319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005251477,"about_ca_system_score_gemma":0.0003856845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007678,"about_ca_topic_score_gemma":0.001707861,"domain_scores_codex":[0.9996898,0.00004302204,0.00001805527,0.00004728445,0.00009537286,0.0001064666],"domain_scores_gemma":[0.9994992,0.0002382484,0.0001114726,0.00006869829,0.00003876242,0.00004353847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005809398,0.00004608788,0.0001824113,0.000152675,0.00002401749,0.0001447846,0.00005479103,0.0001173093,0.9932783,0.0006159316,0.000296243,0.004506465],"study_design_scores_gemma":[0.0001467661,0.0007119059,0.01055673,0.00003014511,0.00004358414,0.0007214117,0.00003896569,0.001832722,0.9820734,0.0002293235,0.003597163,0.00001781616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638925,0.01080555,0.00955693,0.000459696,0.0002001974,0.0002048664,0.0006649201,0.0007000568,0.01351534],"genre_scores_gemma":[0.9919189,0.001738511,0.001233062,0.0001088468,0.00004423157,0.00008003011,0.0003169765,0.00008767604,0.004471864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00373759,"threshold_uncertainty_score":0.0125035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026902059758708,"score_gpt":0.2370884150095443,"score_spread":0.2268193944119573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}