{"id":"W2076646108","doi":"10.1182/blood-2008-02-141770","title":"Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Cancer Research Institute","keywords":"Waldenstrom macroglobulinemia; RNA splicing; Biology; Intron; Macroglobulinemia; Exon; Hyaluronan synthase; Cancer research; Somatic cell; Molecular biology; Bone marrow; Multiple myeloma; Gene; Genetics; Immunology; Lymphoma; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793735,0.000282782,0.0001346056,0.0005422832,0.0001799209,0.0001724566,0.0001270732,0.0002078361,0.0007537284],"category_scores_gemma":[0.0005230722,0.00009817099,0.0001243202,0.000349305,0.000240132,0.000124692,0.0001557925,0.0002330614,0.0001067489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001464849,"about_ca_system_score_gemma":0.0001037364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004261532,"about_ca_topic_score_gemma":0.0005424827,"domain_scores_codex":[0.9998915,0.00002769003,0.00001241737,0.00002287704,0.00002587511,0.00001958774],"domain_scores_gemma":[0.999822,0.00005783556,0.0000723288,0.00000905276,0.000008531999,0.00003027846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001080718,0.00009402735,0.7298151,0.0000830014,0.0001017004,0.007522231,0.000311695,0.0005662842,0.2399013,0.0004767836,0.0001690905,0.0198781],"study_design_scores_gemma":[0.00004917239,0.0003661181,0.9420141,0.00001803367,0.0001158616,0.0282966,0.0001705731,0.00125365,0.02619696,0.0004350761,0.001071386,0.00001245276],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996456,0.0001619335,0.00008852905,0.00000952448,8.260767e-7,0.000001038472,0.00001591721,0.000002772794,0.00007393655],"genre_scores_gemma":[0.9996374,0.00007846931,0.0001613444,0.000007451729,0.000004074921,0.00000132549,0.00004446825,0.000001695865,0.00006386529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007537284,"threshold_uncertainty_score":0.002521455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589097657139114,"score_gpt":0.273867113036514,"score_spread":0.2579761364651229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}