{"id":"W2076700279","doi":"10.1038/icb.2010.65","title":"Innovative bioinformatic approaches for developing peptide‐based vaccines against hypervariable viruses","year":2010,"lang":"en","type":"review","venue":"Immunology and Cell Biology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Carleton University; Variation Biotechnologies (Canada)","funders":"Ontario HIV Treatment Network","keywords":"Hypervariable region; Virology; Epitope; Peptide vaccine; Biology; Computational biology; HIV vaccine; Human immunodeficiency virus (HIV); Genetics; Gene; Antibody; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008623527,0.001001448,0.001193382,0.002013472,0.0002703526,0.001030039,0.001175594,0.001073275,0.002508904],"category_scores_gemma":[0.0006229087,0.0004217572,0.0004756951,0.001993133,0.0006622722,0.001572815,0.0005598192,0.002234979,0.002387735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008660647,"about_ca_system_score_gemma":0.0008738692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006620983,"about_ca_topic_score_gemma":0.0007648107,"domain_scores_codex":[0.9997742,0.00004512475,0.00001971159,0.00003677882,0.0001052676,0.0000190748],"domain_scores_gemma":[0.999739,0.0001279925,0.00003192326,0.00001256728,0.00006779761,0.0000206529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005245492,0.0001432049,0.0001362183,0.006394438,0.00009749968,0.0001683609,0.00006799055,0.00232801,0.009802328,0.01967921,0.01316646,0.9479638],"study_design_scores_gemma":[0.0000377674,0.000129171,0.0005648917,0.001226825,0.00006259897,0.001059021,0.00004220569,0.0007811361,0.004804596,0.009471672,0.9817837,0.00003627666],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006023706,0.9895237,0.005375112,0.0005809965,0.0003244489,0.00002697561,0.000033042,0.0000523035,0.003481008],"genre_scores_gemma":[0.00217817,0.9895331,0.005578449,0.0003894058,0.0002529358,0.00002955399,0.00008044016,0.000008042993,0.001949856],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002508904,"threshold_uncertainty_score":0.008393109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05742911511690522,"score_gpt":0.284573357142675,"score_spread":0.2271442420257698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}