{"id":"W2076700279","doi":"10.1038/icb.2010.65","title":"Innovative bioinformatic approaches for developing peptide‐based vaccines against hypervariable viruses","year":2010,"lang":"en","type":"review","venue":"Immunology and Cell Biology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Carleton University; Variation Biotechnologies (Canada)","funders":"Ontario HIV Treatment Network","keywords":"Hypervariable region; Virology; Epitope; Peptide vaccine; Biology; Computational biology; HIV vaccine; Human immunodeficiency virus (HIV); Genetics; Gene; Antibody; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004481664,0.0007361538,0.001461272,0.0002684683,0.0003042331,0.00005431991,0.0005806635,0.001816854,0.000007759698],"category_scores_gemma":[0.0001772048,0.0005682327,0.0002967228,0.0002847065,0.0002481962,0.00001631016,0.0003679541,0.000562032,0.00002032696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002419861,"about_ca_system_score_gemma":0.0006011944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006066215,"about_ca_topic_score_gemma":0.000005753058,"domain_scores_codex":[0.9975604,0.0001271411,0.001064178,0.0005699389,0.00004313495,0.000635218],"domain_scores_gemma":[0.9981961,0.0001691191,0.0007696908,0.0006423254,0.0001743567,0.00004845021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001300901,0.0001119858,0.00004653167,0.00867966,0.0008133588,7.559466e-7,0.00008092217,0.000004281453,0.005985461,0.002288706,0.0005264108,0.9813318],"study_design_scores_gemma":[0.0008922932,0.0004023342,0.000005959141,0.0003910994,0.0001932219,0.00003391986,0.0001128482,0.0001201921,0.003345879,0.0001079226,0.9936639,0.0007304469],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002061754,0.9904994,0.003640466,0.00003612454,0.0005121818,0.001301579,0.0001688536,0.00003676731,0.001742908],"genre_scores_gemma":[0.0003580982,0.9831801,0.01083738,0.0004403057,0.0002043251,0.0006747508,0.003992461,0.00007845023,0.0002341094],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931375,"threshold_uncertainty_score":0.9996769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05742911511690522,"score_gpt":0.284573357142675,"score_spread":0.2271442420257698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}