{"id":"W2076700889","doi":"10.1139/o00-097","title":"Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Spermine; Cytotoxicity; Glutathione; Chinese hamster ovary cell; Biochemistry; Chemistry; Buthionine sulfoximine; Polyamine; Spermidine; P-glycoprotein; Biology; Molecular biology; Multiple drug resistance; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001605227,0.0003191196,0.0003167813,0.0001610615,0.000124969,0.0002069654,0.000159884,0.0002175704,0.0007005045],"category_scores_gemma":[0.0001143177,0.0001461955,0.000375765,0.0002751702,0.0001593665,0.000142255,0.0001702728,0.00031716,0.0002145456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002748839,"about_ca_system_score_gemma":0.0001665948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392903,"about_ca_topic_score_gemma":0.001840797,"domain_scores_codex":[0.9998108,0.00003336857,0.00002850025,0.00003329237,0.0000555967,0.00003861375],"domain_scores_gemma":[0.9998947,0.00002245727,0.00002893789,0.00002000193,0.00001645572,0.00001733971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005069817,0.00001652314,0.0001183518,0.00001926799,0.000005503173,0.00004692992,0.00001416917,0.0000395216,0.9992441,0.00002672765,0.00001905878,0.0003991433],"study_design_scores_gemma":[0.00001782494,0.0007421573,0.005161325,0.000002821256,0.00001682187,0.0002152425,0.00001732562,0.0007404768,0.9919147,0.0000177329,0.001148041,0.000005510308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967973,0.001033988,0.001014445,0.00004487461,0.00002030372,0.00003242206,0.0002309996,0.0000450103,0.000780753],"genre_scores_gemma":[0.9948686,0.0006885718,0.001712612,0.00004361517,0.000009398492,0.00004161746,0.000699947,0.00001428239,0.001921428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392903,"threshold_uncertainty_score":0.002769589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00667014478434372,"score_gpt":0.2328926296134671,"score_spread":0.2262224848291234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}