{"id":"W2076700889","doi":"10.1139/o00-097","title":"Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells","year":2001,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Spermine; Cytotoxicity; Glutathione; Chinese hamster ovary cell; Biochemistry; Chemistry; Buthionine sulfoximine; Polyamine; Spermidine; P-glycoprotein; Biology; Molecular biology; Multiple drug resistance; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307011,0.0002774005,0.0002544137,0.00004077749,0.00009421477,0.00002323853,0.0001596642,0.0003433224,0.00001872159],"category_scores_gemma":[0.00003676934,0.0002406334,0.00004140702,0.0001217032,0.0002330217,0.000007196671,0.000198176,0.0001592785,0.000002961326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000088303,"about_ca_system_score_gemma":0.00003769151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008427107,"about_ca_topic_score_gemma":0.00002177666,"domain_scores_codex":[0.9986566,0.00005666191,0.0002810444,0.0006194017,0.00005254203,0.0003337671],"domain_scores_gemma":[0.9993304,0.00002398479,0.0001000209,0.0003862516,0.00002647366,0.0001328503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001564642,0.0001428902,0.006571791,0.0000403082,0.000008888916,0.000009901837,0.00002198328,9.116415e-7,0.9910576,0.000005769593,0.0000759187,0.001907533],"study_design_scores_gemma":[0.001134808,0.00006775189,0.008889689,0.00001800259,0.000009473775,0.00003622292,0.00004535238,0.00005345207,0.9792612,0.00005392581,0.01012619,0.0003039993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935119,0.004075193,0.00005602476,0.00008511195,0.00003593609,0.0002042964,0.00009017523,0.0000139382,0.001927402],"genre_scores_gemma":[0.9962422,0.0009520888,0.0005959595,0.0002145357,0.0002483258,0.00004762856,0.0002092822,0.00002077546,0.001469256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01179651,"threshold_uncertainty_score":0.9812745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00667014478434372,"score_gpt":0.2328926296134671,"score_spread":0.2262224848291234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}