{"id":"W2076702686","doi":"10.1021/np1001169","title":"Enantioselective Total Synthesis and X-ray Structures of the Tetrahydroprotoberberine Alkaloids (−)-(<i>S</i>)-Tetrahydropalmatrubine and (−)-(<i>S</i>)-Corytenchine","year":2010,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Enantioselective synthesis; Total synthesis; Stereochemistry; Chemistry; Alkaloid; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006492509,0.000281371,0.0006724668,0.0002668133,0.0001373059,0.00003951896,0.0002275456,0.0001304844,0.00004153373],"category_scores_gemma":[0.0024968,0.0001516935,0.0001536547,0.0006271247,0.0005413242,0.0002738465,0.0001760241,0.001709648,7.740194e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002531273,"about_ca_system_score_gemma":0.0002361561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004979734,"about_ca_topic_score_gemma":0.0000148522,"domain_scores_codex":[0.9978914,0.00009207936,0.0006312049,0.0003160001,0.0007250018,0.0003443017],"domain_scores_gemma":[0.9979933,0.0002047586,0.000439221,0.0003948133,0.0007724905,0.0001954197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003866286,0.0001284798,0.01042901,0.0003109789,0.0001786088,0.00005142752,0.0001555415,0.000002704741,0.9765697,0.0001147714,0.0004431748,0.01122896],"study_design_scores_gemma":[0.00135838,0.0006019665,0.365496,0.0001804464,0.0002036038,0.005724533,0.00005562664,0.00006806808,0.6242005,0.0003535742,0.00157692,0.0001804168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99123,0.002652679,0.000001467419,0.004742146,0.0006031633,0.0005915482,0.000008464135,0.00001222175,0.0001583509],"genre_scores_gemma":[0.9958022,0.000312394,0.002364471,0.00009260593,0.0007644307,0.00000504855,0.000001003164,0.00003313833,0.0006246896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.355067,"threshold_uncertainty_score":0.7427664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600326429646994,"score_gpt":0.2438246354282655,"score_spread":0.2382243089986185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}