{"id":"W2076724914","doi":"10.1158/1538-7445.am10-3510","title":"Abstract 3510: The molecular docking-based design and biological evaluation of a novel series of bisintercalating DNA-binding bisanthrapyrazole compounds containing amine linkers","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Topoisomerase; DNA; Chemistry; Docking (animal); Biochemistry; Enzyme; Doxorubicin; Stereochemistry; Biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067079,0.0005258106,0.0003276071,0.0001626975,0.00008837848,0.0002536901,0.0005065413,0.0002414808,0.001570859],"category_scores_gemma":[0.0001109427,0.0001634137,0.0002107799,0.0001619836,0.00009604817,0.0001665371,0.0001576058,0.0002730276,0.0003949284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003934732,"about_ca_system_score_gemma":0.0002566526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368154,"about_ca_topic_score_gemma":0.001753051,"domain_scores_codex":[0.9999446,0.000008123705,0.000003862192,0.00001284914,0.00002058266,0.00001004319],"domain_scores_gemma":[0.9999629,0.000004273033,0.00001240437,0.000002608567,0.00000824109,0.000009569327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003890424,0.0002849212,0.0005296005,0.0001455597,0.00002896826,0.0001225653,0.00001843711,0.02650397,0.9594579,0.0003484809,0.0001708565,0.01199971],"study_design_scores_gemma":[0.0003150673,0.002922108,0.002690435,0.0000156842,0.00007764793,0.0002432351,0.000020636,0.09759378,0.8915617,0.00007247127,0.004456499,0.00003075518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813549,0.001116325,0.01454893,0.00006538666,0.00001916894,0.0001466412,0.000301412,0.0002747751,0.002172277],"genre_scores_gemma":[0.9791951,0.0008300478,0.01685545,0.00003782398,0.000003648445,0.00008407573,0.0006565167,0.00002577242,0.00231162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570859,"threshold_uncertainty_score":0.005255044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1857361584931573,"score_gpt":0.4273102026070942,"score_spread":0.2415740441139369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}