{"id":"W2076759214","doi":"10.1042/bj20061318","title":"Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides","year":2007,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Science and Technology Agency; Novartis Pharma; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Kanazawa University; Suzuken Memorial Foundation; McMaster University; Daiwa Securities Health Foundation; Japan Research Foundation for Clinical Pharmacology","keywords":"Endoplasmic reticulum; Unfolded protein response; Calreticulin; Calnexin; Chaperone (clinical); Amyloid precursor protein; Cell biology; Biology; Chemistry; Molecular biology; Alzheimer's disease; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006378,0.0003385459,0.0004743109,0.0001398137,0.00007614872,0.0002183953,0.0001482121,0.000187514,0.0007182834],"category_scores_gemma":[0.0001219522,0.00007249562,0.0002431579,0.0001515099,0.0001124573,0.0001138991,0.0001495268,0.0003636464,0.0003974373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009680493,"about_ca_system_score_gemma":0.000121447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001724699,"about_ca_topic_score_gemma":0.0002918563,"domain_scores_codex":[0.999892,0.00002022139,0.00001577435,0.00001497297,0.00003242423,0.00002460545],"domain_scores_gemma":[0.9999087,0.00001496169,0.00002373112,0.00001292258,0.00001792581,0.00002186709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001919144,0.00007244344,0.0001085159,0.00007039173,0.0000112638,0.00005993185,0.000008783527,0.000026424,0.9968303,0.00003425427,0.00006395807,0.002521893],"study_design_scores_gemma":[0.00003086631,0.000743126,0.003384106,0.000006541421,0.00003055562,0.0002481501,0.00001751655,0.0003048622,0.99091,0.00002201055,0.004299477,0.000002864463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886461,0.008040422,0.001369759,0.0001367159,0.0001068547,0.00002900212,0.000214323,0.0001291084,0.001327683],"genre_scores_gemma":[0.9858791,0.006793408,0.00209073,0.00007509984,0.00004621735,0.0000376194,0.0005712548,0.00002663596,0.004479962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007182834,"threshold_uncertainty_score":0.002402961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007091274262891985,"score_gpt":0.2401999221250728,"score_spread":0.2331086478621808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}