{"id":"W2076764177","doi":"10.1016/j.ejmech.2013.06.015","title":"Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Chromone; Alkaline phosphatase; Enzyme; Isozyme; Phosphatase; Sulfonamide; Biochemistry; Non-competitive inhibition; Docking (animal); Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003237453,0.0004552999,0.0002719907,0.0002916252,0.0001303102,0.0002881569,0.000379115,0.0002427239,0.001145436],"category_scores_gemma":[0.0001849783,0.0001416633,0.0001970213,0.0002021624,0.0002761674,0.0002592806,0.0002358494,0.0003862432,0.000270563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003717538,"about_ca_system_score_gemma":0.0003785841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006234525,"about_ca_topic_score_gemma":0.001823434,"domain_scores_codex":[0.999912,0.00001517262,0.000006578399,0.00001183097,0.00002723074,0.00002728184],"domain_scores_gemma":[0.9999292,0.00001325327,0.00001498443,0.000005183323,0.00001635212,0.00002107271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000612121,0.0002281379,0.0006327882,0.0002136827,0.00002720009,0.0003234288,0.00009574635,0.0009788785,0.9723922,0.001386196,0.0005118507,0.0225976],"study_design_scores_gemma":[0.0002254169,0.003207826,0.003700523,0.0000205034,0.00005677527,0.000647552,0.00004780077,0.002026016,0.9744479,0.0001988616,0.01539686,0.00002383323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704259,0.00976434,0.01233213,0.0002200146,0.0001082559,0.000255074,0.0004144475,0.000199648,0.006280079],"genre_scores_gemma":[0.9849315,0.004914239,0.005013545,0.0001098125,0.00002851525,0.00007071403,0.0006214094,0.000009925079,0.004300409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145436,"threshold_uncertainty_score":0.003831804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138760827913698,"score_gpt":0.2725754677573387,"score_spread":0.2586993849659689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}