{"id":"W2076765253","doi":"10.1371/journal.pone.0065801","title":"Resistance to Oncolytic Myxoma Virus Therapy in Nf1−/−/Trp53−/− Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; University of Calgary; Alberta Innovates; Killam Trusts; Terry Fox Foundation; V Foundation for Cancer Research","keywords":"Myxoma virus; Oncolytic virus; Virology; Glioma; Interferon; Virotherapy; Virus; Cancer research; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003050277,0.0005981518,0.0004132275,0.0005366847,0.0001782744,0.0004609028,0.0003081488,0.0005262513,0.001352733],"category_scores_gemma":[0.0001700351,0.0002827189,0.0004482739,0.0001819933,0.0003388723,0.0003490712,0.0001633835,0.001481449,0.0004810069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930793,"about_ca_system_score_gemma":0.0001735006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007368438,"about_ca_topic_score_gemma":0.001041651,"domain_scores_codex":[0.9995998,0.00006663101,0.00006429511,0.00008184373,0.0001081443,0.00007925111],"domain_scores_gemma":[0.9996824,0.00005140474,0.0001070067,0.00005825781,0.00002887141,0.0000720947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191728,0.00006107009,0.000173403,0.0000180666,0.000005666574,0.00003692823,0.00002952819,0.00004561272,0.999006,0.0000800206,0.00002660411,0.0003979053],"study_design_scores_gemma":[0.00001898822,0.00101858,0.002148783,0.00000733393,0.00001283207,0.0003622152,0.00003743236,0.0007186985,0.9946595,0.00006218788,0.0009479829,0.000005479899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954921,0.0006290523,0.002098077,0.00009063391,0.00002767971,0.00006453088,0.0005679918,0.00009058146,0.0009393363],"genre_scores_gemma":[0.9916424,0.0007536052,0.002631698,0.0000618095,0.00001156112,0.000136067,0.0007813405,0.00004290546,0.003938575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352733,"threshold_uncertainty_score":0.004525304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04654056133701073,"score_gpt":0.2859350247484749,"score_spread":0.2393944634114641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}