{"id":"W2076843567","doi":"10.1172/jci80743","title":"Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":270,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"FP7 Health; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Rosetrees Trust; University College London Hospitals NHS Foundation Trust; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust; Academy of Medical Sciences; CHDI Foundation; European Huntington's Disease Network; National Institute for Health and Care Research","keywords":"Huntingtin; Huntington's disease; Cerebrospinal fluid; Huntingtin Protein; Mutant; Disease; Medicine; Biology; Pathology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004524405,0.0004352186,0.0002966249,0.001244543,0.0002737757,0.0005078476,0.000166246,0.0004232886,0.0004262198],"category_scores_gemma":[0.001169625,0.0001216853,0.0001579704,0.0003238808,0.0002242767,0.0001493087,0.000231266,0.0002739755,0.0001928649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002076844,"about_ca_system_score_gemma":0.0001416344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006709286,"about_ca_topic_score_gemma":0.000703685,"domain_scores_codex":[0.9996825,0.0000450691,0.00005197781,0.00007596107,0.0001156885,0.00002875542],"domain_scores_gemma":[0.9995114,0.0001432045,0.0001086956,0.0000268745,0.0001441572,0.00006569511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00108845,0.0001941204,0.4628411,0.0002231411,0.0001853062,0.001890057,0.0007203637,0.0002652983,0.5003343,0.00009058896,0.0006303524,0.03153694],"study_design_scores_gemma":[0.00006132554,0.001587639,0.7489626,0.00009077401,0.0002063045,0.0106954,0.000438672,0.002693104,0.2317953,0.0001945831,0.003236357,0.00003803565],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967001,0.000910397,0.00150829,0.00002902635,0.00002211628,0.00002427866,0.0003696046,0.00006689089,0.0003692226],"genre_scores_gemma":[0.995138,0.0003055894,0.003525273,0.00007384277,0.00002523785,0.00002633581,0.0006832232,0.00000856853,0.0002139478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244543,"threshold_uncertainty_score":0.002392769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.145223287029583,"score_gpt":0.3666846870905437,"score_spread":0.2214614000609607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}