{"id":"W2076845452","doi":"10.1038/mt.2009.242","title":"Risk in Clinical Research: Size Matters!","year":2009,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Business","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3235364,0.003299045,0.009056111,0.00724171,0.004788656,0.0296177,0.009715021,0.02761064,0.02168374],"category_scores_gemma":[0.5859781,0.002143444,0.003508582,0.006259163,0.04065799,0.03828221,0.01214945,0.04157904,0.01894543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008086058,"about_ca_system_score_gemma":0.03070073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003235557,"about_ca_topic_score_gemma":0.003740897,"domain_scores_codex":[0.6450335,0.1965896,0.03348636,0.01320516,0.1079081,0.003777223],"domain_scores_gemma":[0.1751415,0.6360747,0.02856277,0.05553697,0.08229944,0.02238457],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005966452,0.0001282674,0.001461598,0.005799403,0.0006361058,0.0003449132,0.001325659,0.0002874219,0.0003186922,0.05745652,0.7407551,0.1908897],"study_design_scores_gemma":[0.0006548043,0.0003229623,0.001386727,0.0127947,0.0003618248,0.0009547161,0.001515157,0.0007713299,0.0003359416,0.1804735,0.8001689,0.0002593556],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002114282,0.04446081,0.003920211,0.8926688,0.05015749,0.0002800213,0.0001268174,0.0002675047,0.007906834],"genre_scores_gemma":[0.01930107,0.07481834,0.02511272,0.7071136,0.1610725,0.002481274,0.0003270801,0.0008908469,0.00888251],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.6764636,"threshold_uncertainty_score":0.8342001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1111302620915015,"score_gpt":0.439335480235887,"score_spread":0.3282052181443855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}