{"id":"W2076887683","doi":"10.1016/j.freeradbiomed.2007.11.003","title":"The role of redox-sensitive transcription factors NF-κB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper","year":2007,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Activator (genetics); Oxidative stress; Heme oxygenase; Reactive oxygen species; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Glutathione; Gene expression; NF-κB; Messenger RNA; Signal transduction; Transcription factor; Heme; Molecular biology; Cell biology; Biochemistry; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007072523,0.0007385007,0.0004538067,0.0007688294,0.0006491334,0.0008103776,0.0006943842,0.000622836,0.001883616],"category_scores_gemma":[0.0005231864,0.0004276857,0.0006003735,0.0003482474,0.0007624247,0.00100792,0.0004751382,0.00102921,0.0004780228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007975476,"about_ca_system_score_gemma":0.00051944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209594,"about_ca_topic_score_gemma":0.001346333,"domain_scores_codex":[0.9995765,0.00009872744,0.00003588002,0.00007586079,0.00009637818,0.0001166926],"domain_scores_gemma":[0.9994336,0.0001414771,0.0001278139,0.0000656409,0.0001116095,0.0001197835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002458995,0.0001910218,0.001568975,0.0002822311,0.00003983816,0.0004433368,0.000299562,0.0002369233,0.9863183,0.001653514,0.0001968,0.006310374],"study_design_scores_gemma":[0.0002386039,0.0006762737,0.0301388,0.00009275572,0.0001676034,0.001619524,0.0007402918,0.003774239,0.9525996,0.003032283,0.00686379,0.00005636343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474816,0.03074855,0.01548386,0.001614214,0.0002112985,0.00007301821,0.0005695384,0.0001991627,0.003618722],"genre_scores_gemma":[0.984319,0.005639833,0.003389078,0.0001834144,0.00008765247,0.00008709211,0.0004386856,0.00002906829,0.005826209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001883616,"threshold_uncertainty_score":0.006301343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672553105506089,"score_gpt":0.242427505319939,"score_spread":0.2357019742648781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}