{"id":"W2076887683","doi":"10.1016/j.freeradbiomed.2007.11.003","title":"The role of redox-sensitive transcription factors NF-κB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper","year":2007,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Activator (genetics); Oxidative stress; Heme oxygenase; Reactive oxygen species; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Glutathione; Gene expression; NF-κB; Messenger RNA; Signal transduction; Transcription factor; Heme; Molecular biology; Cell biology; Biochemistry; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004358029,0.00009473805,0.0001592949,0.00001698645,0.00007574305,0.000001626309,0.0001080584,0.0001603247,9.780563e-7],"category_scores_gemma":[0.0001779889,0.00004508117,0.00002403706,0.00004397763,0.001494006,0.000002204368,0.00003709476,0.0001135987,2.993453e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003675656,"about_ca_system_score_gemma":0.00001003362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009327219,"about_ca_topic_score_gemma":0.0001024073,"domain_scores_codex":[0.9993131,0.0001159527,0.0002084753,0.0001720141,0.00005893536,0.0001315136],"domain_scores_gemma":[0.9995641,0.0001240705,0.00008094731,0.0001636052,0.00003151016,0.00003583753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001211081,0.00001738154,0.01637125,0.000006736182,0.00002419713,1.570266e-7,0.0004421943,2.59167e-7,0.9790347,0.0004032255,0.0002376165,0.003341198],"study_design_scores_gemma":[0.0008941105,0.0003302566,0.1198661,0.00001868066,0.00003118529,0.00001004097,0.001210669,0.00002693954,0.8700596,0.002248371,0.005235163,0.00006885788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892258,0.008818955,0.0002624918,0.001248848,0.00005791139,0.0001673702,0.00004424941,0.000001163398,0.000173212],"genre_scores_gemma":[0.9978582,0.001724415,0.0000311737,0.0002158114,0.00008316242,0.000002415587,0.00006710686,0.000003848108,0.00001383402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1089751,"threshold_uncertainty_score":0.5504729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672553105506089,"score_gpt":0.242427505319939,"score_spread":0.2357019742648781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}