{"id":"W2076888798","doi":"10.2353/ajpath.2009.080611","title":"Atherosclerosis in LDLR-Knockout Mice Is Inhibited, but Not Reversed, by the PPARγ Ligand Pioglitazone","year":2009,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Key Research and Development Program of China; Gross Foundation; National Institutes of Health; Abercrombie Foundation","keywords":"Pioglitazone; LDL receptor; Knockout mouse; Ligand (biochemistry); Gene knockout; Receptor; Internal medicine; Medicine; Endocrinology; Pharmacology; Biology; Chemistry; Cholesterol; Biochemistry; Lipoprotein; Diabetes mellitus; Gene; Type 2 diabetes","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004840494,0.0002273852,0.000420468,0.0001127209,0.00007243486,0.00001866635,0.0003996638,0.0001600513,0.00001748049],"category_scores_gemma":[0.0001593674,0.000169734,0.0001623821,0.0002990441,0.0004923897,0.00001225094,0.00005998546,0.0004317397,0.00001094831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005035293,"about_ca_system_score_gemma":0.00009646256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002959816,"about_ca_topic_score_gemma":0.000004866976,"domain_scores_codex":[0.9982943,0.0002984323,0.0005323419,0.0003023199,0.0001921028,0.0003805255],"domain_scores_gemma":[0.9988457,0.00003854116,0.0005453481,0.0003034965,0.0001406367,0.0001263044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002953111,0.000121871,0.002473353,0.000001811329,0.00003829027,0.00003011944,0.0004349767,0.000007599771,0.9856383,0.000004201294,0.003896084,0.007058144],"study_design_scores_gemma":[0.001032721,0.002115727,0.002801971,0.00002694677,0.00002708706,0.0007421238,0.0009965942,0.000002893557,0.9821507,0.00003245479,0.009851442,0.0002193216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959325,0.0007207622,0.0002449423,0.002675592,0.0001458512,0.0001008187,0.00003525306,0.000005530485,0.0001387613],"genre_scores_gemma":[0.9917237,0.0008773447,0.0006180421,0.006310716,0.0002174929,0.000004249268,0.000008720021,0.0000238025,0.000215964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006838823,"threshold_uncertainty_score":0.6921551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007089999970634517,"score_gpt":0.2381793817218226,"score_spread":0.231089381751188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}