{"id":"W2076890666","doi":"10.1371/journal.pone.0081870","title":"AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"AMPK; Lipogenesis; Catabolism; AMP-activated protein kinase; Glucose uptake; Beta oxidation; Protein kinase A; Mitochondrion; Chemistry; Biology; Biochemistry; Fatty acid; Internal medicine; Cell biology; Endocrinology; Adipose tissue; Metabolism; Kinase; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003174407,0.001026422,0.000807873,0.0007400803,0.0002713204,0.0004846377,0.0003941696,0.0004573381,0.001246215],"category_scores_gemma":[0.0001360069,0.0002683902,0.0004301559,0.0006030668,0.0003547039,0.0003344845,0.0003229358,0.00141884,0.0003913028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003143525,"about_ca_system_score_gemma":0.0002316535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002601078,"about_ca_topic_score_gemma":0.000395469,"domain_scores_codex":[0.9996173,0.00007612559,0.00006441002,0.00007729881,0.00009932664,0.00006537481],"domain_scores_gemma":[0.9998645,0.00001165364,0.0000550965,0.00002229705,0.0000119608,0.00003453636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009407995,0.0002306215,0.0001716538,0.0001104217,0.00002207531,0.00007894187,0.00001027969,0.00008997355,0.9947073,0.00006562435,0.00008488357,0.003487373],"study_design_scores_gemma":[0.0001172857,0.001992619,0.002423701,0.00001525826,0.00006241327,0.0003201021,0.00001913351,0.0004423909,0.9923916,0.00006089448,0.002145055,0.000009497904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785075,0.009079603,0.0078407,0.000502781,0.0002245386,0.0001190129,0.0008886749,0.0004877219,0.00234935],"genre_scores_gemma":[0.9678692,0.01370866,0.01059729,0.000316344,0.0001166292,0.0003173251,0.001934533,0.0001245501,0.005015498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246215,"threshold_uncertainty_score":0.004168987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591151167243434,"score_gpt":0.2161511856231114,"score_spread":0.190239673950677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}