{"id":"W2076908570","doi":"10.1021/bi048251y","title":"Photolabeling Study of the Ligand Binding Domain of Natriuretic Peptide Receptor A: Development of a Model","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"","keywords":"NPR2; Peptide; Natriuretic peptide; Receptor; NPR1; Chemistry; Cyclic guanosine monophosphate; Atrial natriuretic peptide; Peptide sequence; Amino acid; Binding site; Homology modeling; Biochemistry; Ligand (biochemistry); Protein structure; Biophysics; Biology; Internal medicine; Endocrinology; Medicine; Nitric oxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765022,0.000125451,0.0002266277,0.00001973461,0.00004354925,0.000003354202,0.000278099,0.0001133935,0.00001177821],"category_scores_gemma":[0.00008478536,0.00009563571,0.0001386758,0.0001358443,0.00006839419,0.000001476961,0.0001571788,0.00006106665,5.0841e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002064696,"about_ca_system_score_gemma":0.0001048269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000504577,"about_ca_topic_score_gemma":0.000006408748,"domain_scores_codex":[0.998961,0.00001527003,0.000452224,0.0002324829,0.0002089379,0.000130041],"domain_scores_gemma":[0.9992486,0.00001235995,0.0002688568,0.0003435522,0.00008689423,0.00003973714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003005361,0.0003310562,0.001718975,0.00006832839,0.000117455,4.948737e-8,0.0002715183,0.0001114188,0.9968,6.569615e-7,0.000107219,0.0004432429],"study_design_scores_gemma":[0.0003738498,0.00002364367,0.00006078515,0.00006264853,0.00004497239,6.251337e-7,0.0005982006,0.0001663963,0.9984013,0.000003216507,0.0001591088,0.0001052112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992546,0.0003317321,0.0000736818,0.00002268284,0.00001096389,0.00008853957,0.00001599414,0.000002476792,0.0001993516],"genre_scores_gemma":[0.9963699,0.00001747065,0.003302531,0.000006855501,0.00004458883,0.000008117101,0.00001200905,0.0000113291,0.0002272298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003228849,"threshold_uncertainty_score":0.3899911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103496600808905,"score_gpt":0.2359294586236765,"score_spread":0.225579798542786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}