{"id":"W2076922802","doi":"10.1002/glia.20836","title":"Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells","year":2008,"lang":"en","type":"article","venue":"Glia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"","keywords":"Glial fibrillary acidic protein; Amyotrophic lateral sclerosis; Spinal cord; Biology; Pathogenesis; Pathology; Motor neuron; Neuroglia; Downregulation and upregulation; Schwann cell; Astrocyte; Neuroscience; Immunohistochemistry; Central nervous system; Anatomy; Medicine; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429567,0.0002244684,0.0005509819,0.0002723861,0.00006156884,0.00001021435,0.0001711343,0.0001027529,0.000635219],"category_scores_gemma":[0.00005760856,0.0002003645,0.0001680275,0.0004348227,0.0002825598,0.0002083485,0.0001054763,0.0002707932,0.00005765993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001323026,"about_ca_system_score_gemma":0.0001770855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004828804,"about_ca_topic_score_gemma":0.000002176436,"domain_scores_codex":[0.9977603,0.0001838886,0.0006035925,0.0004075854,0.0006068872,0.0004377347],"domain_scores_gemma":[0.9988137,0.00003413821,0.0002135924,0.0004448426,0.0002122252,0.0002815152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001407638,0.0003212281,0.260038,0.000191956,0.00003949963,0.00008172602,0.0004107318,0.000001160199,0.735324,8.21807e-7,0.0008662072,0.00131702],"study_design_scores_gemma":[0.002479032,0.0001326439,0.959897,0.0004787225,0.0000507402,0.00001155063,0.00003465616,0.0002524681,0.03635502,0.00001697916,0.0001221669,0.0001690501],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975956,0.0005390933,0.00001030315,0.0007664553,0.0001025777,0.0006306064,0.0002912843,0.00003128696,0.0000327965],"genre_scores_gemma":[0.9977534,0.001098612,0.0002411625,0.0002075259,0.00008039772,0.00006702402,0.00009345405,0.00004036611,0.0004180355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.699859,"threshold_uncertainty_score":0.8170626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981558859219194,"score_gpt":0.2546921812034575,"score_spread":0.2248765926112656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}