{"id":"W2076962443","doi":"10.1016/j.neuint.2013.11.008","title":"Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance","year":2013,"lang":"en","type":"article","venue":"Neurochemistry International","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; Vanderbilt University Medical Center","keywords":"Cholinergic; Choline acetyltransferase; Acetylcholine; Acetylcholinesterase; Endocrinology; Internal medicine; Vesicular acetylcholine transporter; Transgene; Biology; Genetically modified mouse; Choline; Cholinergic neuron; Aché; Biochemistry; Enzyme; Medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256179,0.0006222682,0.0005567473,0.0005314669,0.0002791867,0.0004537859,0.0004927868,0.0006863408,0.003398987],"category_scores_gemma":[0.0001537543,0.0003273364,0.0004379422,0.0002607887,0.0007192193,0.000345016,0.0003167411,0.00134442,0.0006504947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005923579,"about_ca_system_score_gemma":0.0003506279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001997445,"about_ca_topic_score_gemma":0.003318664,"domain_scores_codex":[0.9998006,0.00001353227,0.00001884543,0.00005310862,0.00004689055,0.00006703847],"domain_scores_gemma":[0.9997279,0.00003292893,0.00008798619,0.00002521948,0.00002446326,0.0001015442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003641572,0.00008466957,0.00008305021,0.00001827793,0.00001055382,0.00005328541,0.00001389283,0.00002798739,0.9985473,0.00007010764,0.00005253064,0.0006741286],"study_design_scores_gemma":[0.000123401,0.0007448826,0.004809374,0.00001455256,0.0001082567,0.0002270918,0.0001088456,0.0009669536,0.9911488,0.0001148306,0.001616157,0.00001681903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952853,0.0005296892,0.002178397,0.0002346258,0.0001024628,0.00002302637,0.0003960292,0.0002860597,0.0009643364],"genre_scores_gemma":[0.9892473,0.0005918283,0.00120406,0.00008042598,0.00002625762,0.00005281542,0.000463297,0.0001072009,0.008226828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003398987,"threshold_uncertainty_score":0.01137072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007066901990994236,"score_gpt":0.2321242666742485,"score_spread":0.2250573646832543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}