{"id":"W2076973862","doi":"10.1021/jm100513m","title":"A-CD Estrogens. I. Substituent Effects, Hormone Potency, and Receptor Subtype Selectivity in a New Family of Flexible Estrogenic Compounds","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Toronto; Carleton University","funders":"","keywords":"Chemistry; Potency; Estrogen; Estrogen receptor; Quinone; Receptor; Hormone receptor; Hormone; Stereochemistry; Substituent; Internal medicine; Endocrinology; Biochemistry; In vitro; Cancer; Breast cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603128,0.0001749893,0.0001229497,0.0001708462,0.000127843,0.0001896111,0.0001677717,0.0001857225,0.001160943],"category_scores_gemma":[0.0001710487,0.000122257,0.00014064,0.0001895285,0.0003028478,0.0002263795,0.0001581671,0.0003143426,0.0002199823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838582,"about_ca_system_score_gemma":0.0001357784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004032291,"about_ca_topic_score_gemma":0.0005983117,"domain_scores_codex":[0.9999307,0.00001356066,0.000004423271,0.00002053663,0.00002349666,0.000007231325],"domain_scores_gemma":[0.9999275,0.00002589876,0.00001675303,0.000009589837,0.00001079878,0.000009300152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004747193,0.00009034206,0.001040032,0.0002605997,0.00001491292,0.0001401144,0.00004273664,0.004679047,0.9527186,0.006793882,0.00062227,0.0331228],"study_design_scores_gemma":[0.0001693038,0.003343237,0.003349925,0.00003602448,0.00006499885,0.0009233131,0.00005746598,0.01243925,0.9278588,0.002175561,0.04954708,0.00003500137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9253003,0.01645304,0.03689052,0.0006484602,0.0001179677,0.0001436174,0.0006456847,0.0002109152,0.01958954],"genre_scores_gemma":[0.9661835,0.004226618,0.02402686,0.0001830597,0.0000308723,0.00005788694,0.0001795822,0.00001302323,0.005098651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160943,"threshold_uncertainty_score":0.003883779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003796278250025938,"score_gpt":0.2248007843598421,"score_spread":0.2210045061098161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}