{"id":"W2076981629","doi":"10.1021/cc8001525","title":"Discovery of Indoline-Based, Natural-Product-like Compounds as Probes of Focal Adhesion Kinase Signaling Pathways","year":2009,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Focal adhesion; Natural product; Small molecule; Signal transduction; Chemistry; In vitro; Indoline; Cell biology; Kinase; Cell adhesion molecule; Wound healing; MTT assay; Biochemistry; Biology; Stereochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007332922,0.0002434235,0.00082342,0.0001607547,0.00004826754,0.00002951009,0.0003557875,0.0001805042,0.00003973407],"category_scores_gemma":[0.0009213856,0.0001989196,0.0004287411,0.000369279,0.0001642864,0.0001801579,0.0000679146,0.0009148294,0.000001751197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001689408,"about_ca_system_score_gemma":0.001022221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000754032,"about_ca_topic_score_gemma":6.126987e-8,"domain_scores_codex":[0.996766,0.00008166476,0.001109886,0.0002383464,0.001509001,0.0002951251],"domain_scores_gemma":[0.9971434,0.0002144491,0.0008693934,0.0004004906,0.001148645,0.0002235929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004031153,0.001287902,0.0005844953,0.0006701347,0.00006282325,0.0002750708,0.00004901548,0.00003586251,0.9914893,0.0001214167,0.0008426948,0.0005501584],"study_design_scores_gemma":[0.005836349,0.001545562,0.0005113405,0.0009305229,0.0001075382,0.0001955761,0.00008165226,0.00006737159,0.9884819,0.001743365,0.0003388859,0.0001598712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996733,0.001276863,0.00003256351,0.0004210245,0.0006926921,0.0001941251,0.00000535517,0.00001152709,0.0006328159],"genre_scores_gemma":[0.9982851,0.00005587817,0.0005055219,0.00006203933,0.0008776809,0.000001293884,0.00001716842,0.00002483931,0.0001705393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003007307,"threshold_uncertainty_score":0.8111707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467691897440692,"score_gpt":0.2778677461984774,"score_spread":0.2631908272240704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}