{"id":"W2076981629","doi":"10.1021/cc8001525","title":"Discovery of Indoline-Based, Natural-Product-like Compounds as Probes of Focal Adhesion Kinase Signaling Pathways","year":2009,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Focal adhesion; Natural product; Small molecule; Signal transduction; Chemistry; In vitro; Indoline; Cell biology; Kinase; Cell adhesion molecule; Wound healing; MTT assay; Biochemistry; Biology; Stereochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811937,0.0003265416,0.0003366534,0.0004065322,0.0001154916,0.00022913,0.0003381299,0.0001952777,0.001449092],"category_scores_gemma":[0.0001768987,0.0001457527,0.0002270235,0.0002146438,0.0001410912,0.0001916192,0.0001681583,0.0002867677,0.0003278974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048967,"about_ca_system_score_gemma":0.0002122853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001642556,"about_ca_topic_score_gemma":0.0006033251,"domain_scores_codex":[0.9999397,0.00002045724,0.000003916049,0.00001066691,0.00001344803,0.00001176862],"domain_scores_gemma":[0.9999295,0.00001651806,0.00001617234,0.000006415102,0.00001391885,0.00001740752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002182972,0.0001777269,0.0003657938,0.0001570224,0.00001892289,0.0002000771,0.00003636867,0.000896191,0.9849491,0.0004270828,0.0001362827,0.01241727],"study_design_scores_gemma":[0.0002152441,0.003061543,0.002745557,0.00002672346,0.00007644868,0.0006513996,0.00003754273,0.00193432,0.9830595,0.0002512155,0.007921736,0.00001879172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776025,0.005897924,0.01104885,0.0001354632,0.00002448193,0.000314118,0.0005712488,0.00013693,0.004268369],"genre_scores_gemma":[0.9766665,0.003371624,0.01622071,0.0001061061,0.00001915544,0.0001554902,0.0008349151,0.00001840075,0.002607018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449092,"threshold_uncertainty_score":0.004847646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467691897440692,"score_gpt":0.2778677461984774,"score_spread":0.2631908272240704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}