{"id":"W2076994662","doi":"10.1016/j.jbiotec.2007.01.006","title":"Embryonic stem cells remain highly pluripotent following long term expansion as aggregates in suspension bioreactors","year":2007,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health Services; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Stem Cell Network","keywords":"Embryoid body; Induced pluripotent stem cell; Embryonic stem cell; Cell biology; Biology; Bioreactor; Population; Genetics; Botany; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006012188,0.000339242,0.0005847332,0.0004146803,0.000391367,0.001270095,0.0004472159,0.0005583602,0.001873443],"category_scores_gemma":[0.0004977861,0.0002824633,0.0004521956,0.0003808347,0.0003279383,0.0008689525,0.0005775705,0.00115138,0.001862795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003344775,"about_ca_system_score_gemma":0.0002182013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004692392,"about_ca_topic_score_gemma":0.0007688565,"domain_scores_codex":[0.9995534,0.00005179016,0.00008155579,0.00007458786,0.0001499756,0.00008869741],"domain_scores_gemma":[0.9988654,0.0003243693,0.0001727029,0.0002235485,0.000225137,0.0001889532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000687573,0.00003158659,0.0008164185,0.00001883317,0.0000124483,0.00009849336,0.00005459209,0.0001028317,0.9963825,0.0002372017,0.0001956394,0.001980644],"study_design_scores_gemma":[0.00001933822,0.0001680271,0.007894401,0.00001238104,0.00006880156,0.0004083449,0.0001203678,0.001159254,0.9844428,0.0003897543,0.005303,0.00001353707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605945,0.003568294,0.02631728,0.000509945,0.0001735935,0.00008229149,0.002771431,0.0003471597,0.005635447],"genre_scores_gemma":[0.9792235,0.0008426726,0.004614434,0.0002678796,0.00006905101,0.00006259192,0.004798105,0.0001333752,0.009988463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873443,"threshold_uncertainty_score":0.00626725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006007761688726,"score_gpt":0.2636315883050334,"score_spread":0.2535715106881462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}