{"id":"W2076996275","doi":"10.1021/ac801538c","title":"Measurement of Ring A-Reduced Progesterone Metabolites by Enzyme-Linked Immunoassay with Colorimetric Detection: Baseline Levels of Six Metabolites, Including Pregnanolone, in Male Rat Plasma","year":2009,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Pregnanolone; Allopregnanolone; Radioimmunoassay; Neuroactive steroid; Immunoassay; Chromatography; Enzyme; Pregnane; Steroid; Detection limit; Biochemistry; Receptor; Stereochemistry; Antibody; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006406583,0.001011671,0.0003416432,0.0007099302,0.0003503207,0.0004428854,0.0003977565,0.000624756,0.001025694],"category_scores_gemma":[0.001271175,0.0003806291,0.0002931081,0.0006088502,0.0005027695,0.0003959985,0.0002545201,0.000675377,0.0007076274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003568223,"about_ca_system_score_gemma":0.000580413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009766193,"about_ca_topic_score_gemma":0.001114788,"domain_scores_codex":[0.9991359,0.0001878768,0.00005148562,0.0002364554,0.0002887433,0.00009963952],"domain_scores_gemma":[0.9992816,0.0001452086,0.0001678289,0.0001063663,0.0001699136,0.0001291335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005023177,0.00007141161,0.001711812,0.0000370333,0.0000200864,0.00003484466,0.00003284274,0.00005156984,0.9937392,0.00004246967,0.00003580768,0.003720483],"study_design_scores_gemma":[0.00003481737,0.001609134,0.01316164,0.000004809837,0.00004703222,0.0002103073,0.00002473831,0.0006057852,0.983681,0.00006038676,0.0005467455,0.00001361372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9522181,0.004198002,0.03953217,0.0001377962,0.00008092366,0.0001810419,0.000762069,0.0007055975,0.002184297],"genre_scores_gemma":[0.9456525,0.002263457,0.04534092,0.0001936371,0.00008689817,0.0005506263,0.001428084,0.00007535243,0.004408559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025694,"threshold_uncertainty_score":0.00343132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570283694673861,"score_gpt":0.24728801642391,"score_spread":0.2315851794771714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}