{"id":"W2077000316","doi":"10.1523/jneurosci.2245-07.2007","title":"Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic<i>Xenopus laevis</i>Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Rhodopsin; Retinitis pigmentosa; Retinal degeneration; Xenopus; Biology; Cell biology; Retinal; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188455,0.0006046642,0.000395847,0.0002945693,0.0002691271,0.0004053792,0.0003479742,0.0004679428,0.001213149],"category_scores_gemma":[0.0001195933,0.000288936,0.0004300025,0.0001250609,0.0003857202,0.0002402948,0.0003211909,0.0009636171,0.0005223135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004712146,"about_ca_system_score_gemma":0.0003040736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002913609,"about_ca_topic_score_gemma":0.00304437,"domain_scores_codex":[0.9997719,0.0000344691,0.00004153575,0.00005752693,0.00004581206,0.00004870445],"domain_scores_gemma":[0.9996827,0.0000432682,0.0001276698,0.00003410186,0.00002345046,0.00008888519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004352364,0.00001560908,0.000057887,0.00001622268,0.000002963174,0.00005755342,0.00001699325,0.00002387525,0.9995486,0.000035359,0.00001379112,0.0001676059],"study_design_scores_gemma":[0.00001740091,0.0002200914,0.002435927,0.000008030809,0.00001256929,0.0002326895,0.00005260812,0.0005064454,0.9952526,0.00002533025,0.001228469,0.000007786771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937744,0.0006605711,0.002951635,0.0001427382,0.00004474697,0.00005291341,0.0009452859,0.0002377764,0.001189749],"genre_scores_gemma":[0.9883277,0.0007047012,0.003253581,0.0000840489,0.00001095927,0.00007482789,0.0009174285,0.0002002351,0.006426633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002913609,"threshold_uncertainty_score":0.005793273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215203273513533,"score_gpt":0.2620314335346964,"score_spread":0.2398794007995611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}