{"id":"W2077017078","doi":"10.1016/j.bbrc.2010.10.131","title":"A site-specific genomic integration strategy for sustained expression of glucagon-like peptide-1 in mouse muscle for controlling energy homeostasis","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Glucose homeostasis; Proglucagon; Transgene; Biology; Energy homeostasis; Incretin; Glucagon-like peptide-1; Homeostasis; Molecular biology; Cell biology; Internal medicine; Chemistry; Endocrinology; Gene; Biochemistry; Insulin; Receptor; Diabetes mellitus; Type 2 diabetes; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004044209,0.0005641443,0.0003038145,0.0005810648,0.000280436,0.0004545089,0.0005793618,0.0006256334,0.001239958],"category_scores_gemma":[0.0002684188,0.0005137118,0.0005768677,0.0003456842,0.0004627679,0.0003011223,0.0004137253,0.001386222,0.0005323052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990263,"about_ca_system_score_gemma":0.0003937739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007054328,"about_ca_topic_score_gemma":0.00191471,"domain_scores_codex":[0.9996425,0.00004818324,0.00004363213,0.0001100965,0.00008236992,0.00007320699],"domain_scores_gemma":[0.9997632,0.00004475765,0.00008598562,0.00003345381,0.00001900249,0.0000537758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004547654,0.00001923229,0.00004561366,0.00001403059,0.000004260438,0.00003721839,0.00001497642,0.0000628305,0.9982944,0.0003116216,0.00002581095,0.001124554],"study_design_scores_gemma":[0.00006311673,0.000307542,0.001436108,0.00001229925,0.00007417179,0.0003514833,0.00003966826,0.001660033,0.9921319,0.0001579155,0.003750375,0.00001537383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9103177,0.001756219,0.08085144,0.0005226734,0.0003383801,0.0004864171,0.001677896,0.0007587512,0.003290635],"genre_scores_gemma":[0.9483784,0.000895222,0.043819,0.0001833277,0.00004440019,0.0001830948,0.00154443,0.000192627,0.004759506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239958,"threshold_uncertainty_score":0.004148066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0740704337744566,"score_gpt":0.3545655212009857,"score_spread":0.2804950874265291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}