{"id":"W2077067229","doi":"10.1038/cdd.2010.76","title":"Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death","year":2010,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Protein kinase R; eIF2; Phosphorylation; Integrated stress response; Cell biology; Cytoprotection; Kinase; Biology; EIF-2 kinase; Protein kinase A; Programmed cell death; Phosphorylation cascade; Translation (biology); Protein phosphorylation; Cyclin-dependent kinase 2; Apoptosis; Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557131,0.0003351686,0.0003639884,0.0001617608,0.0001771151,0.0002952444,0.0001421852,0.0002129168,0.002873834],"category_scores_gemma":[0.0001904847,0.0001378894,0.0001892161,0.0000924266,0.0002957848,0.0003499805,0.0001832009,0.0006765437,0.0006313677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648303,"about_ca_system_score_gemma":0.0003804595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008183592,"about_ca_topic_score_gemma":0.002018246,"domain_scores_codex":[0.9999063,0.00001582437,0.000009855947,0.00001877195,0.00001501804,0.00003421009],"domain_scores_gemma":[0.9998617,0.00003563301,0.00002476677,0.00003366241,0.00001000004,0.00003412242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005678132,0.00007154059,0.000201402,0.00005956436,0.000007582898,0.00006217902,0.00001893382,0.0001296358,0.9948526,0.0002897129,0.0002379377,0.003501149],"study_design_scores_gemma":[0.00008856129,0.000676355,0.003614975,0.000009911041,0.00001134881,0.0002980705,0.00002658757,0.0005608576,0.9921148,0.00008871692,0.00249898,0.00001072974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989954,0.001967442,0.004250491,0.0003611585,0.0001775022,0.00005314601,0.000540332,0.0002668423,0.002429095],"genre_scores_gemma":[0.9949329,0.0007930855,0.001067715,0.00005162539,0.00001646744,0.00002303178,0.0003247124,0.00002212479,0.002768247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002873834,"threshold_uncertainty_score":0.009613931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00393919494455084,"score_gpt":0.2014396301764155,"score_spread":0.1975004352318647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}