{"id":"W2077067229","doi":"10.1038/cdd.2010.76","title":"Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death","year":2010,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Protein kinase R; eIF2; Phosphorylation; Integrated stress response; Cell biology; Cytoprotection; Kinase; Biology; EIF-2 kinase; Protein kinase A; Programmed cell death; Phosphorylation cascade; Translation (biology); Protein phosphorylation; Cyclin-dependent kinase 2; Apoptosis; Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006466523,0.0001209346,0.00009795336,0.00003208675,0.0001011047,0.00003227008,0.00004964323,0.000119078,0.00001008477],"category_scores_gemma":[0.00008259158,0.00008684459,0.00003604864,0.00004361875,0.00004627795,0.000008493501,0.0000372682,0.00007193989,0.000001517158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003360171,"about_ca_system_score_gemma":0.00002494795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002627636,"about_ca_topic_score_gemma":0.00001556865,"domain_scores_codex":[0.99941,0.00004779115,0.0001296741,0.0002099484,0.00009207272,0.000110528],"domain_scores_gemma":[0.9995371,0.00004411344,0.0001138569,0.0001579393,0.00006872474,0.00007823253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006013274,0.00008062039,0.06181241,0.00008703089,0.000009928536,3.041283e-7,0.00008219554,0.000001901852,0.9367593,0.0001314018,0.00002506258,0.0009497277],"study_design_scores_gemma":[0.000581794,0.00009445773,0.4240362,0.000005172652,0.00003337535,7.410097e-7,0.00001720352,0.0006952535,0.5741494,0.0002336412,0.00008101048,0.00007178266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99691,0.0006724122,0.001473675,0.00003485224,0.00009259712,0.0004071507,0.000009253577,0.00001024117,0.0003898139],"genre_scores_gemma":[0.9992374,0.0001445408,0.0001318856,0.00004406751,0.00005791795,0.00002767893,0.0001524356,0.00001046005,0.0001935837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3626099,"threshold_uncertainty_score":0.354142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00393919494455084,"score_gpt":0.2014396301764155,"score_spread":0.1975004352318647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}