{"id":"W2077097921","doi":"10.1016/j.immuni.2014.12.011","title":"Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis","year":2014,"lang":"en","type":"article","venue":"Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; amfAR, The Foundation for AIDS Research; National Cancer Institute; National Institutes of Health; Center for AIDS Research, University of Washington; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation; National Institute on Drug Abuse","keywords":"Necroptosis; Programmed cell death; Biology; Downregulation and upregulation; CD8; Cytotoxic T cell; Apoptosis; Cell growth; T cell; Caspase; Cell biology; Cancer research; Immunology; Antigen; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243148,0.0003334374,0.0001741093,0.000364755,0.0001419825,0.0003935735,0.0001628031,0.0003038925,0.001698302],"category_scores_gemma":[0.0001405328,0.0001510863,0.0001700264,0.0001664011,0.0002708575,0.0002598352,0.0001896516,0.0007146267,0.0003338728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458118,"about_ca_system_score_gemma":0.0001075453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001026552,"about_ca_topic_score_gemma":0.0001325423,"domain_scores_codex":[0.9998513,0.00003126299,0.00001440664,0.00003505151,0.00002509753,0.00004271185],"domain_scores_gemma":[0.9998827,0.00001432243,0.00005164551,0.00001583378,0.000009599032,0.00002591059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003859924,0.00003903964,0.001233984,0.00004450395,0.000009048013,0.0004102456,0.00001638796,0.00004075361,0.9957494,0.000146805,0.00006243016,0.001861429],"study_design_scores_gemma":[0.00005686869,0.0003839799,0.05035447,0.0000185995,0.00003820344,0.006618571,0.0001145536,0.001140648,0.9386478,0.0004752987,0.002142005,0.000009105579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953512,0.001925152,0.001219266,0.00007914852,0.0000264534,0.00001761355,0.0002850302,0.00008351997,0.001012583],"genre_scores_gemma":[0.9978393,0.0004430602,0.0006392787,0.00002484713,0.00001158568,0.00001637447,0.0002053418,0.000007704356,0.0008125223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698302,"threshold_uncertainty_score":0.005681455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005826737467839882,"score_gpt":0.1884135175767163,"score_spread":0.1825867801088764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}