{"id":"W2077097921","doi":"10.1016/j.immuni.2014.12.011","title":"Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis","year":2014,"lang":"en","type":"article","venue":"Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; amfAR, The Foundation for AIDS Research; National Cancer Institute; National Institutes of Health; Center for AIDS Research, University of Washington; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation; National Institute on Drug Abuse","keywords":"Necroptosis; Programmed cell death; Biology; Downregulation and upregulation; CD8; Cytotoxic T cell; Apoptosis; Cell growth; T cell; Caspase; Cell biology; Cancer research; Immunology; Antigen; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411143,0.0001392055,0.0001202307,0.00002892324,0.000220345,0.0000377686,0.00005983243,0.0001748915,0.00006352716],"category_scores_gemma":[0.00004708946,0.0001190004,0.00003024013,0.00008320112,0.00005668652,0.000009062644,0.00004209633,0.0001131497,0.000005367701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000239122,"about_ca_system_score_gemma":0.00003603922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001704243,"about_ca_topic_score_gemma":0.00007290019,"domain_scores_codex":[0.999212,0.0001707,0.0001061722,0.0002253738,0.0001396628,0.0001460661],"domain_scores_gemma":[0.9994649,0.00003269444,0.00009824706,0.0002208784,0.000111772,0.00007155437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459233,0.0001402918,0.002496943,0.000006688525,0.00003193649,2.862362e-7,0.00004166364,0.000009250844,0.9938792,0.000009809763,0.001994041,0.001243984],"study_design_scores_gemma":[0.00183128,0.0005043148,0.05390574,0.00001322506,0.00003507001,0.000006350312,0.00003426283,0.001979857,0.9310128,0.00003980334,0.01035047,0.0002868006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936551,0.0001454601,0.005416468,0.0001035914,0.00004530708,0.000162265,0.00006539209,0.00001978813,0.0003866522],"genre_scores_gemma":[0.9975684,0.00009332688,0.0001128249,0.0001392213,0.00005415111,0.00001588502,0.001493851,0.00001726159,0.0005050313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06286636,"threshold_uncertainty_score":0.4852696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005826737467839882,"score_gpt":0.1884135175767163,"score_spread":0.1825867801088764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}