{"id":"W2077109220","doi":"10.1093/nar/gkm620","title":"Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites","year":2007,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Hypersensitive site; Locus control region; Biology; DNase I hypersensitive site; Chromatin; Deoxyribonuclease I; Molecular biology; Globin; Nucleosome; Histone; Activator (genetics); Gene; Genetics; Cell biology; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001372644,0.00009814394,0.00008603436,0.00008762274,0.0000814936,0.0001480234,0.0001184451,0.00009482099,0.00139281],"category_scores_gemma":[0.0001441198,0.0000931327,0.00007835356,0.00005661135,0.0001295472,0.00009411358,0.0001560977,0.0001758224,0.0002896893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539577,"about_ca_system_score_gemma":0.0001296149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007181571,"about_ca_topic_score_gemma":0.001515224,"domain_scores_codex":[0.9998994,0.00001419525,0.000004367247,0.00003419309,0.00002733184,0.00002049742],"domain_scores_gemma":[0.9999255,0.00001465912,0.00001562529,0.00001120952,0.00001084154,0.00002215208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003796107,0.000002460676,0.0007129771,0.000009437487,0.000002469111,0.00001206831,0.00001120584,0.00002489545,0.9981089,0.0001073487,0.00001702691,0.0009532284],"study_design_scores_gemma":[0.00001765109,0.0001516309,0.04170281,0.000007736108,0.00001701005,0.0003907558,0.00004358691,0.001055163,0.9523799,0.0001808499,0.004049307,0.000003573276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928197,0.001584535,0.003043522,0.00004672141,0.00000855999,0.000008826947,0.0002201167,0.00003832953,0.002229788],"genre_scores_gemma":[0.996698,0.0002988051,0.000682152,0.00003076292,0.000002644198,0.00000754731,0.000408015,0.000006947088,0.001865134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139281,"threshold_uncertainty_score":0.004659414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03907834884742259,"score_gpt":0.3315021981404762,"score_spread":0.2924238492930537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}