{"id":"W2077115092","doi":"10.1016/j.atherosclerosis.2014.07.005","title":"MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1","year":2014,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Alberta; University of Calgary; University of Saskatchewan","funders":"National Institutes of Health; Natural Science Foundation of Hunan Province; National Institutes of Natural Sciences; National Natural Science Foundation of China","keywords":"ABCA1; Cholesterol; Reverse cholesterol transport; Western blot; Apolipoprotein E; Apolipoprotein B; Lipoprotein; Liver X receptor; Biology; microRNA; Foam cell; Macrophage; Apolipoprotein A1; Transporter; Cell biology; Chemistry; Biochemistry; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":{"nature":"Expression of concern","reason":"Concerns/Issues about Data;Investigation by Company/Institution;Investigation by Third Party;","date":"6/29/2021 0:00","openalex_flagged":false},"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004491947,0.0004626649,0.000621956,0.0003999197,0.0004549168,0.0006497249,0.000293912,0.0005774684,0.003075221],"category_scores_gemma":[0.0004072758,0.0004545176,0.0005342413,0.0002046161,0.0004404348,0.0002892367,0.0004679711,0.001217309,0.0009119036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004712251,"about_ca_system_score_gemma":0.0005160659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008315947,"about_ca_topic_score_gemma":0.001273318,"domain_scores_codex":[0.9995583,0.00009073798,0.00004154137,0.0000882664,0.00009670437,0.000124333],"domain_scores_gemma":[0.9998282,0.00002419805,0.00004630282,0.00001625572,0.00002582543,0.00005923575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002093544,0.0002054798,0.001177892,0.00009775131,0.00005818568,0.0002242803,0.00003686383,0.0001002977,0.990894,0.0004572548,0.0007404417,0.003914023],"study_design_scores_gemma":[0.0008733606,0.002351291,0.03522829,0.00004129679,0.0003345731,0.001496491,0.0002492425,0.004934567,0.9330781,0.0007151967,0.0206564,0.0000412503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847203,0.004397838,0.004407819,0.001051959,0.000715633,0.00005793698,0.000605485,0.0002771079,0.003765892],"genre_scores_gemma":[0.9914085,0.001327887,0.002136899,0.0004569712,0.00007954575,0.00009495697,0.0005397311,0.00009468388,0.00386071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003075221,"threshold_uncertainty_score":0.01028758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095669111683994,"score_gpt":0.2604118200118754,"score_spread":0.2394551288950354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}