{"id":"W2077130594","doi":"10.3762/bjoc.7.142","title":"A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of <i>N'</i>-benzyl-<i>N,N</i>-dimethylureas","year":2011,"lang":"en","type":"article","venue":"Beilstein Journal of Organic Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"Cardiff University","keywords":"Chemistry; Substitution (logic); Simple (philosophy); Combinatorial chemistry; Medicinal chemistry; Computational chemistry; Organic chemistry; Programming language; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186077,0.0003313017,0.0002486686,0.0001667216,0.0001395589,0.0001180207,0.0003696157,0.0001313648,0.001244771],"category_scores_gemma":[0.0001165972,0.0001484692,0.0001679717,0.0001206721,0.0001153047,0.0001946802,0.0001692277,0.000340159,0.0004521529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344189,"about_ca_system_score_gemma":0.0002297672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000197289,"about_ca_topic_score_gemma":0.0006391408,"domain_scores_codex":[0.9999291,0.00001026497,0.000009442155,0.00001598372,0.00001550818,0.00001979311],"domain_scores_gemma":[0.999953,0.000006188191,0.00001420581,0.000008669974,0.000007562317,0.00001036272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008305609,0.00003325923,0.000127083,0.0001385727,0.00000583043,0.0001468989,0.00005082393,0.0001854495,0.9900911,0.0004690267,0.00007780463,0.008591048],"study_design_scores_gemma":[0.00001687256,0.0003261711,0.0008833121,0.000005468969,0.000008956181,0.0003369689,0.00001342236,0.0002419157,0.9936596,0.00006985429,0.004427173,0.00001033309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593011,0.003558765,0.02606769,0.000109481,0.0000653235,0.000206955,0.0006574731,0.0003669574,0.009666275],"genre_scores_gemma":[0.9805748,0.001832345,0.01374907,0.00003125556,0.00001096903,0.00008208008,0.0004251733,0.00003671226,0.003257524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244771,"threshold_uncertainty_score":0.004164219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987176353258868,"score_gpt":0.2279284308086871,"score_spread":0.2080566672760984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}