{"id":"W2077134681","doi":"10.1007/s00401-004-0905-4","title":"A two-hour window for hypothermic modulation of early events that impact delayed opening of the rat blood-brain barrier after ischemia","year":2004,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Thermal Regulation in Medicine","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Institute for Biological Sciences","funders":"","keywords":"Hypothermia; Medicine; Ischemia; Neuroprotection; Blood–brain barrier; Anesthesia; Edema; Brain ischemia; Stroke (engine); Brain damage; Pharmacology; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003209708,0.0009327244,0.001034456,0.0002630095,0.0003980785,0.0007003185,0.0004958667,0.0006148267,0.004348852],"category_scores_gemma":[0.0003706946,0.0002657082,0.0005558859,0.0002838739,0.0007681418,0.001020663,0.0005288062,0.001791296,0.0003981977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004477871,"about_ca_system_score_gemma":0.0007906627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006264129,"about_ca_topic_score_gemma":0.001609043,"domain_scores_codex":[0.9998457,0.00001465359,0.00001188578,0.00002997521,0.00001635868,0.00008134053],"domain_scores_gemma":[0.9997575,0.00003971674,0.00006570577,0.00004968291,0.00002045564,0.00006691256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02367629,0.0005205215,0.0004121845,0.0001608975,0.00003575042,0.0001808587,0.0001301177,0.0001574998,0.9683762,0.000558231,0.0002673578,0.005524001],"study_design_scores_gemma":[0.0007915225,0.01092595,0.009354821,0.00006234329,0.0002124131,0.0002024752,0.0001956201,0.0006165183,0.974748,0.0005045641,0.002326512,0.00005928936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896819,0.00358782,0.004221826,0.0002275607,0.0003692525,0.0001740916,0.0005369255,0.0001652579,0.001035417],"genre_scores_gemma":[0.9928777,0.00226822,0.001974869,0.0001467603,0.00015225,0.0004158576,0.0004737051,0.00004446287,0.001646278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004348852,"threshold_uncertainty_score":0.01454836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02038398734222283,"score_gpt":0.2904231161855678,"score_spread":0.270039128843345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}