{"id":"W2077173862","doi":"10.1038/nrc1819","title":"Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis","year":2006,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1223,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"PTEN; Tensin; PI3K/AKT/mTOR pathway; Cancer research; Biology; Regulator; Carcinogenesis; Crosstalk; Suppressor; Phosphatase; Signal transduction; Cell biology; Genetics; Cancer; Gene; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007135239,0.001350871,0.00207746,0.001738523,0.0004094359,0.001524553,0.001823471,0.002483792,0.002440684],"category_scores_gemma":[0.0006333506,0.000353799,0.0005032895,0.002170873,0.001266898,0.002201064,0.001027504,0.003049254,0.002190694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001293007,"about_ca_system_score_gemma":0.001205307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009089551,"about_ca_topic_score_gemma":0.001491303,"domain_scores_codex":[0.999755,0.00003851106,0.00002817298,0.00003851429,0.0001032475,0.00003662072],"domain_scores_gemma":[0.9996874,0.0001236794,0.00003329782,0.00001749245,0.00008859906,0.00004963993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003115062,0.00007050392,0.000340746,0.006249152,0.0001104083,0.001370299,0.00007522673,0.001280031,0.01369267,0.01342904,0.05534242,0.907728],"study_design_scores_gemma":[0.00008777342,0.000168921,0.001891655,0.001950749,0.0001800156,0.00789291,0.000116234,0.0004985852,0.005083322,0.01465055,0.9674269,0.00005226546],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003161181,0.9956725,0.0007537,0.001043067,0.0005626361,0.000005524788,0.00002132377,0.00003162404,0.001593511],"genre_scores_gemma":[0.001820272,0.9963771,0.0002664978,0.0003882255,0.0003275039,0.000006732965,0.00002143196,0.000003216742,0.0007889966],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002483792,"threshold_uncertainty_score":0.009381413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987870137344663,"score_gpt":0.3492838676675714,"score_spread":0.3294051662941248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}