{"id":"W2077192003","doi":"10.1007/s00044-010-9334-1","title":"Synthesis and antiprotozoal activity of 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin A-4","year":2010,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Provincial Laboratory of Public Health","funders":"Howard Hughes Medical Institute","keywords":"Antiprotozoal; Plasmodium falciparum; Chemistry; Combretastatin; Cytotoxicity; Giardia lamblia; Trypanosoma cruzi; IC50; Giardia; Leishmania; Biochemistry; In vitro; Stereochemistry; Tubulin; Microbiology; Biology; Microtubule; Parasite hosting; Cell biology; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001891233,0.0001949825,0.0005632853,0.00005652068,0.0001039072,0.00001263664,0.0004143915,0.0003031716,0.003557106],"category_scores_gemma":[0.00374159,0.000143887,0.00009665352,0.0002768621,0.001603632,0.00005726721,0.0002189447,0.00114619,0.000001992437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002363892,"about_ca_system_score_gemma":0.0001129043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000307268,"about_ca_topic_score_gemma":0.00001022362,"domain_scores_codex":[0.9977987,0.0000873654,0.0003534328,0.0004348198,0.0008848116,0.0004408958],"domain_scores_gemma":[0.9966231,0.002202309,0.0001807616,0.0004713787,0.0002946824,0.0002277944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003014719,0.0004020053,0.02204525,0.001097772,0.00004255078,0.00001117584,0.00003244121,8.413726e-8,0.9463902,0.0000276132,0.00007629772,0.02957319],"study_design_scores_gemma":[0.0002901411,0.00006908632,0.008926128,0.0001460773,0.00002303158,0.00002837587,0.0001670485,0.0001692887,0.9894792,0.0002137598,0.0003567306,0.0001311593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758886,0.00007796899,0.000005546966,0.0002794937,0.00001766939,0.00009730718,0.0000889696,0.00002093914,0.02352347],"genre_scores_gemma":[0.999406,0.0000654174,0.0001422097,0.000003311897,0.0001440746,0.000039731,0.000006130879,0.00001412322,0.0001790047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04308902,"threshold_uncertainty_score":0.9973538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06279041611696261,"score_gpt":0.3494190480496367,"score_spread":0.2866286319326741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}