{"id":"W2077192003","doi":"10.1007/s00044-010-9334-1","title":"Synthesis and antiprotozoal activity of 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin A-4","year":2010,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Provincial Laboratory of Public Health","funders":"Howard Hughes Medical Institute","keywords":"Antiprotozoal; Plasmodium falciparum; Chemistry; Combretastatin; Cytotoxicity; Giardia lamblia; Trypanosoma cruzi; IC50; Giardia; Leishmania; Biochemistry; In vitro; Stereochemistry; Tubulin; Microbiology; Biology; Microtubule; Parasite hosting; Cell biology; Immunology; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251912,0.0002701537,0.000318005,0.0002838614,0.0002145761,0.0002052761,0.0004352744,0.0002101416,0.001759882],"category_scores_gemma":[0.0001587738,0.000162438,0.0002112789,0.0001855798,0.0001633011,0.0001646751,0.0001280459,0.0003335022,0.0004282905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003017975,"about_ca_system_score_gemma":0.0003391915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048747,"about_ca_topic_score_gemma":0.001505424,"domain_scores_codex":[0.9999259,0.00001869582,0.000009758121,0.00001205244,0.00001401821,0.0000195827],"domain_scores_gemma":[0.9999303,0.000008085777,0.00002286446,0.000008795714,0.000008697826,0.00002122102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001328288,0.000189363,0.0001897554,0.000198651,0.00002633279,0.0004389667,0.0000708762,0.001447575,0.9761219,0.000675309,0.0004454486,0.01886754],"study_design_scores_gemma":[0.0007869831,0.006547812,0.002248291,0.00001956617,0.00007104767,0.0008745028,0.00004054665,0.002539582,0.9694707,0.0001560232,0.01721195,0.00003288845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825796,0.004805169,0.00374969,0.0001938059,0.0001256955,0.0002457617,0.001004346,0.0001825585,0.00711332],"genre_scores_gemma":[0.9900578,0.002536565,0.00310521,0.0000594207,0.00003927499,0.00006253786,0.0008651547,0.00002029041,0.003253823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759882,"threshold_uncertainty_score":0.005887389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06279041611696261,"score_gpt":0.3494190480496367,"score_spread":0.2866286319326741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}