{"id":"W2077196962","doi":"10.1007/s00044-011-9694-1","title":"Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents","year":2011,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University; Sudbury Regional Hospital","funders":"All India Council for Technical Education","keywords":"Chemistry; Chloroquine; Potency; Stereochemistry; IC50; Antimalarial Agent; Plasmodium falciparum; Combinatorial chemistry; Lead compound; Pharmacology; In vitro; Traditional medicine; Malaria; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005519376,0.0002543927,0.0004902828,0.00006079278,0.0001852821,0.00002213546,0.0004624593,0.0004575503,0.01040539],"category_scores_gemma":[0.005417996,0.0001754243,0.00008914324,0.0002150881,0.0009718681,0.00009567831,0.0002821107,0.000546288,0.00001984358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198032,"about_ca_system_score_gemma":0.0001935111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001901595,"about_ca_topic_score_gemma":5.540542e-7,"domain_scores_codex":[0.9965107,0.0002837063,0.000430511,0.0006574934,0.001533994,0.0005835589],"domain_scores_gemma":[0.9974582,0.001245585,0.0001542996,0.0004095917,0.0004722629,0.0002600851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005620373,0.0004976438,0.004545963,0.0001864289,0.00008658677,0.00001775761,0.0001109836,6.228506e-7,0.984722,0.00003651857,0.00008564372,0.009147848],"study_design_scores_gemma":[0.0007723674,0.000162947,0.006152919,0.0001693021,0.00007388903,0.00004963281,0.0003508774,0.0009233943,0.9893115,0.001720238,0.0001093051,0.0002036085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818906,0.0004327854,0.00004565186,0.0001556701,0.00003338541,0.0001825965,0.0000303422,0.00003701997,0.01719193],"genre_scores_gemma":[0.9988025,0.0002223706,0.0003315074,0.00001517647,0.000356616,0.000112391,0.00001401331,0.00001633615,0.0001290908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01706284,"threshold_uncertainty_score":0.9904993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4753258298901895,"score_gpt":0.4086908280950866,"score_spread":0.06663500179510284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}