{"id":"W2077242674","doi":"10.1074/jbc.m601843200","title":"Human Homologs of Ubc6p Ubiquitin-conjugating Enzyme and Phosphorylation of HsUbc6e in Response to Endoplasmic Reticulum Stress","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Endoplasmic reticulum; Endoplasmic-reticulum-associated protein degradation; Ubiquitin-conjugating enzyme; Ubiquitin; Phosphorylation; Ubiquitin ligase; Cell biology; Unfolded protein response; Biology; Biochemistry; Transmembrane protein; Subcellular localization; Deubiquitinating enzyme; Cytoplasm; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007484972,0.0001593551,0.0001476877,0.0001439735,0.0001469848,0.0001119829,0.00009887184,0.0002191483,0.0006839852],"category_scores_gemma":[0.000114532,0.00009567212,0.0001720845,0.0001802972,0.0001413218,0.00007970964,0.0001413985,0.0001994277,0.0002089606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540815,"about_ca_system_score_gemma":0.00009835173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007095487,"about_ca_topic_score_gemma":0.0005655411,"domain_scores_codex":[0.9999094,0.00001015267,0.000007503496,0.00002515334,0.00002615645,0.00002171254],"domain_scores_gemma":[0.9999185,0.000006978148,0.00002444117,0.000008953636,0.00001026884,0.0000309012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003768286,0.00002166272,0.002949619,0.0000285276,0.00001024729,0.0001869205,0.00002109331,0.0001139563,0.9949092,0.00007411284,0.00005468862,0.001253189],"study_design_scores_gemma":[0.00003432929,0.0004645899,0.2398706,0.000008791179,0.00003095849,0.004010221,0.00007503085,0.001964661,0.7492105,0.0001972644,0.004119918,0.00001323643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983475,0.0005742285,0.0003654987,0.00003631862,0.000005723944,0.000009416941,0.0002869429,0.00001264955,0.000361673],"genre_scores_gemma":[0.9972791,0.0002122618,0.0005829153,0.00003254581,0.000003458711,0.00001070099,0.0008069774,0.00000317832,0.001068913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007095487,"threshold_uncertainty_score":0.002288163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00831567955402675,"score_gpt":0.2461312144619563,"score_spread":0.2378155349079295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}