{"id":"W2077257393","doi":"10.1210/en.2006-0229","title":"Isoform-Specific Regulation of Uridine Diphosphate-Glucuronosyltransferase 2B Enzymes in the Human Prostate: Differential Consequences for Androgen and Bioactive Lipid Inactivation","year":2006,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"","keywords":"LNCaP; Glucuronidation; Internal medicine; Endocrinology; Androgen; Glucuronosyltransferase; Chemistry; Dihydrotestosterone; Prostate cancer; Uridine; Biology; Microsome; Enzyme; Biochemistry; Cancer; Hormone; Medicine; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002390895,0.0001981069,0.0002927266,0.0001666266,0.0002107578,0.00001560269,0.0001699494,0.0001352265,0.0001431463],"category_scores_gemma":[0.0000178576,0.0001575064,0.00006235544,0.0001557502,0.0005221542,0.0001057341,0.00003023716,0.000275951,0.000002048868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002621096,"about_ca_system_score_gemma":0.00003562448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000116129,"about_ca_topic_score_gemma":0.00004578132,"domain_scores_codex":[0.9984466,0.0003337066,0.0004284207,0.0002960639,0.00009582096,0.0003993896],"domain_scores_gemma":[0.9992163,0.0003736868,0.0001634844,0.0001253473,0.00007853079,0.00004271709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007122763,0.0004474226,0.02322023,0.00005925057,0.00007943928,0.00000964212,0.0009813776,0.0001484538,0.8634649,0.09877747,0.0005297014,0.01156982],"study_design_scores_gemma":[0.003351789,0.0001941266,0.06359636,0.000005323456,0.00008257286,0.00002689349,0.0001753998,0.0001895802,0.8728701,0.006853436,0.05248652,0.0001678918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933484,0.00334951,0.0002360724,0.0010306,0.000429687,0.0009499975,0.0001586439,0.00002373296,0.0004733224],"genre_scores_gemma":[0.9982215,0.0008678125,0.00007940252,0.0001519684,0.0002504576,0.0001952789,0.0001439813,0.00001475743,0.00007481024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09192403,"threshold_uncertainty_score":0.6422924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06114825669709596,"score_gpt":0.3725159786298214,"score_spread":0.3113677219327255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}