{"id":"W2077269148","doi":"10.1093/neuonc/nou206.72","title":"COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Phosphoproteomics; Cytotoxicity; Biology; Computational biology; Drug discovery; High-content screening; Drug; Cyclin-dependent kinase; Pharmacology; Bioinformatics; Cancer research; Kinase; Cell; Genetics; In vitro; Cell cycle; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003449464,0.0007605575,0.001014226,0.001098124,0.0003301417,0.0005637624,0.0003899916,0.0003360114,0.002056423],"category_scores_gemma":[0.0001995376,0.0002189532,0.000597742,0.001086747,0.0002340033,0.0001979338,0.0002739216,0.0005104461,0.0006597498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008181986,"about_ca_system_score_gemma":0.0007018867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003705443,"about_ca_topic_score_gemma":0.01259063,"domain_scores_codex":[0.9997455,0.00002368888,0.00002120092,0.00005686011,0.00009698221,0.00005565333],"domain_scores_gemma":[0.9998534,0.00003310109,0.00002314039,0.00001341213,0.00004985618,0.00002714643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002951043,0.000120736,0.001930661,0.0001342502,0.00003830874,0.00006216978,0.0000158939,0.0006161493,0.9908004,0.00003505214,0.0001773322,0.005773993],"study_design_scores_gemma":[0.00005817606,0.001556178,0.02683412,0.000009798736,0.0001462513,0.0004148536,0.00004061905,0.002055353,0.9668897,0.00005186884,0.001930036,0.00001303871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777679,0.00423289,0.006392364,0.0001868557,0.00002438966,0.0002677047,0.008045417,0.0002920548,0.002790392],"genre_scores_gemma":[0.9624805,0.005134827,0.01426587,0.0001938125,0.0000192495,0.0002533704,0.01432946,0.00006444819,0.003258365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003705443,"threshold_uncertainty_score":0.00736773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100091870679388,"score_gpt":0.2525429151871301,"score_spread":0.2415419964803362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}