{"id":"W2077275224","doi":"10.1016/j.bbmt.2011.07.015","title":"Development and Validation of a Test Dose Strategy for Once-Daily i.v. Busulfan: Importance of Fixed Infusion Rate Dosing","year":2011,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Risk and Safety Analysis","field":"Decision Sciences","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"Otsuka America","keywords":"Medicine; Dosing; Busulfan; Test (biology); Pharmacology; Internal medicine; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007163759,0.0008731373,0.001437286,0.0006973602,0.0003012616,0.001376854,0.001859081,0.0009314195,0.0006077045],"category_scores_gemma":[0.01052407,0.0006206305,0.0006297889,0.0006454471,0.0006154111,0.0007130777,0.0004761672,0.001219904,0.0004174509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026966,"about_ca_system_score_gemma":0.002033881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002050361,"about_ca_topic_score_gemma":0.001620653,"domain_scores_codex":[0.9965222,0.001763985,0.0002154679,0.0004106089,0.0009513841,0.0001362717],"domain_scores_gemma":[0.9951372,0.001530576,0.001213677,0.0006044725,0.001206556,0.0003075858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01145017,0.00497443,0.01953177,0.0005691707,0.0003198247,0.000103717,0.0004648272,0.03065589,0.6936896,0.001028612,0.001172212,0.2360397],"study_design_scores_gemma":[0.001343716,0.07663833,0.02048297,0.00008405426,0.0005354314,0.0008474871,0.0001355541,0.1478276,0.7422152,0.0005053506,0.009251928,0.0001323085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7141347,0.002765856,0.2724991,0.0004038015,0.0001344739,0.006268095,0.0009855983,0.001343101,0.001465187],"genre_scores_gemma":[0.7001739,0.001355182,0.2938975,0.0002407063,0.00006071721,0.002183505,0.00106345,0.0002957091,0.0007294182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007163759,"threshold_uncertainty_score":0.03788602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08799323891200726,"score_gpt":0.3209608685477165,"score_spread":0.2329676296357093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}