{"id":"W2077277924","doi":"10.1016/j.jaad.2005.10.061","title":"A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis","year":2006,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Centre de Recherche Dermatologique du Québec Métropolitain; Probity Medical Research; Innovaderm (Canada)","funders":"","keywords":"Medicine; Psoriasis; Placebo; Psoriasis Area and Severity Index; Body surface area; Internal medicine; Calcineurin; Creatinine; Renal function; Plaque psoriasis; Randomized controlled trial; Clinical endpoint; Gastroenterology; Adverse effect; Urology; Dermatology; Pathology; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001493047,0.002367635,0.004706983,0.0007298722,0.0007863202,0.001399171,0.001291191,0.002967471,0.009969139],"category_scores_gemma":[0.001806453,0.00107293,0.0018129,0.0005086409,0.001783523,0.001636009,0.0005032996,0.004507723,0.001966287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006088585,"about_ca_system_score_gemma":0.001278094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094615,"about_ca_topic_score_gemma":0.001985422,"domain_scores_codex":[0.9994276,0.0002491343,0.00002682018,0.0001097259,0.00004529015,0.0001414309],"domain_scores_gemma":[0.9993344,0.0001806221,0.0001040323,0.00005803494,0.00005850874,0.000264381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9779114,0.007538728,0.0002525873,0.0004841425,0.000671858,0.00003990151,0.00004652848,0.0001917846,0.002089474,0.0001175428,0.0009081629,0.009747934],"study_design_scores_gemma":[0.9749138,0.02401741,0.0004291193,0.00001127933,0.0001433284,0.00001311961,0.00001498319,0.00009580687,0.0001014946,0.00005560429,0.0001965788,0.000007472659],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814962,0.00482704,0.0009704605,0.001363773,0.001249524,0.005023994,0.001182005,0.0003501576,0.003536898],"genre_scores_gemma":[0.9788347,0.003615125,0.001760606,0.002482704,0.0008046588,0.005415266,0.001590032,0.00006365019,0.005433201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009969139,"threshold_uncertainty_score":0.03335011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328885326937976,"score_gpt":0.2799231877384183,"score_spread":0.2666343344690386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}