{"id":"W2077277924","doi":"10.1016/j.jaad.2005.10.061","title":"A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis","year":2006,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Centre de Recherche Dermatologique du Québec Métropolitain; Probity Medical Research; Innovaderm (Canada)","funders":"","keywords":"Medicine; Psoriasis; Placebo; Psoriasis Area and Severity Index; Body surface area; Internal medicine; Calcineurin; Creatinine; Renal function; Plaque psoriasis; Randomized controlled trial; Clinical endpoint; Gastroenterology; Adverse effect; Urology; Dermatology; Pathology; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004821761,0.0002778661,0.002484488,0.000424356,0.00005908815,0.000004370396,0.0005058947,0.0002248056,0.00004023929],"category_scores_gemma":[0.0000991563,0.0001579043,0.0006094276,0.000324445,0.0009683418,0.0001085099,0.00005826376,0.0004597787,0.000006237848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008325993,"about_ca_system_score_gemma":0.000178585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443957,"about_ca_topic_score_gemma":0.00002135476,"domain_scores_codex":[0.9963189,0.001356703,0.001643372,0.0001851342,0.0001358167,0.0003600084],"domain_scores_gemma":[0.9948776,0.0008984685,0.003924804,0.0001720991,0.00009841335,0.00002858928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9831007,0.001813365,0.008820076,0.00002017275,0.001558606,0.000007582254,0.0001294024,0.0000457208,0.002476529,0.0001029241,0.0002786318,0.001646299],"study_design_scores_gemma":[0.9737781,0.0009820175,0.00201567,0.00008042054,0.001028965,0.0001537007,0.00004232484,0.000006605197,0.02115619,0.00004959738,0.0005678543,0.0001385556],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949052,0.001783941,0.00002691182,0.001194901,0.0004635955,0.00151057,0.00002512129,0.000006310073,0.0000833936],"genre_scores_gemma":[0.9993145,0.000281,0.0001086555,0.00007382764,0.00007566233,0.00005372532,0.000008894022,0.00001843862,0.00006529865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01867966,"threshold_uncertainty_score":0.6439149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328885326937976,"score_gpt":0.2799231877384183,"score_spread":0.2666343344690386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}