{"id":"W2077300582","doi":"10.1073/pnas.0400099101","title":"Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"DNA repair; Methyl methanesulfonate; Biology; DNA damage; Small interfering RNA; Molecular biology; DNA; Cell biology; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004689039,0.00007795545,0.000101373,0.00008848844,0.0001108866,0.00001228548,0.0002326404,0.00006628873,0.000005082491],"category_scores_gemma":[0.0001492919,0.000062084,0.00003853238,0.0002148298,0.0002601506,0.00002693988,0.0000836626,0.00003756466,4.897803e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002029801,"about_ca_system_score_gemma":0.0000281871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003152387,"about_ca_topic_score_gemma":0.000001513892,"domain_scores_codex":[0.9989489,0.000004706422,0.0002365493,0.0002198007,0.0004827709,0.0001072606],"domain_scores_gemma":[0.9995356,0.00001097573,0.0002121009,0.00001138911,0.000196548,0.00003339865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001097416,0.00002417435,0.00008916045,0.00003288065,0.000008684899,3.853681e-8,0.0001335776,0.0007563788,0.9945732,0.004256289,0.00001524203,0.000099415],"study_design_scores_gemma":[0.0001405274,0.0001686951,0.008790717,0.00004479786,0.000008730693,0.00001765001,0.0001107796,0.0000704452,0.974088,0.0164891,0.00000593601,0.00006468383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990239,0.00006217646,0.000009003768,0.0002121542,0.00001549111,0.0001969661,0.0000160049,0.000004243534,0.000460056],"genre_scores_gemma":[0.9951509,0.00001219183,0.004624089,0.00009988787,0.00003197422,0.000004201974,7.909662e-7,0.000004142214,0.00007186578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02048525,"threshold_uncertainty_score":0.2531712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597434557421142,"score_gpt":0.2722207792630336,"score_spread":0.2562464336888222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}