{"id":"W2077360795","doi":"10.1158/1538-7445.am2012-4381","title":"Abstract 4381: The novel direct-acting vascular targeting agent NGR-TNF exerts <i>in vivo</i> antitumor activity by inducing endothelial and tumor cell death in the absence of proangiogenic bone-marrow derived cell recruitment","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Cancer research; Lewis lung carcinoma; Angiogenesis; Bone marrow; Tumor necrosis factor alpha; Medicine; Homing (biology); Osteopontin; Cytokine; Tumor microenvironment; Immunology; Biology; Cancer; Immune system; Metastasis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008639834,0.0003796648,0.0001816003,0.0001281539,0.00008576406,0.0001408067,0.0001766708,0.0002432656,0.004820284],"category_scores_gemma":[0.00005450714,0.0000648977,0.0001190722,0.00009796404,0.0001205457,0.0001267534,0.00008381681,0.0003968475,0.001404696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183819,"about_ca_system_score_gemma":0.0002033223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003088883,"about_ca_topic_score_gemma":0.0004033039,"domain_scores_codex":[0.9999329,0.00001226978,0.000006016011,0.00001292844,0.0000206384,0.0000153451],"domain_scores_gemma":[0.9999534,0.000004901112,0.00001572984,0.00000459978,0.000006072265,0.00001523904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009422664,0.000208668,0.0001249115,0.000108483,0.000008058262,0.0001170665,0.000008521227,0.0001322912,0.9884446,0.0002705662,0.0006702123,0.008964357],"study_design_scores_gemma":[0.0002344278,0.002612602,0.001675979,0.00001383191,0.00002456247,0.0007709846,0.000007632646,0.0005318568,0.9775334,0.00006088924,0.01652975,0.000004028052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438529,0.009792722,0.009209445,0.0005943334,0.0003925623,0.0002222432,0.001474065,0.0005116304,0.03395004],"genre_scores_gemma":[0.9706438,0.002604739,0.003865339,0.0001643382,0.0001496176,0.0000746928,0.001483471,0.00003622004,0.02097779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004820284,"threshold_uncertainty_score":0.01612544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09705653656665787,"score_gpt":0.3617733054287148,"score_spread":0.264716768862057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}