{"id":"W2077366253","doi":"10.1074/jbc.m400247200","title":"A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"DNA fragmentation; Fragmentation (computing); Block (permutation group theory); DNA; Apoptotic DNA fragmentation; Biophysics; Chemistry; Computational biology; Cell biology; Molecular biology; Biology; Apoptosis; Biochemistry; Programmed cell death; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004442882,0.0005983742,0.0005702111,0.0003140389,0.0001481984,0.0003553905,0.0004209118,0.0006568368,0.001412308],"category_scores_gemma":[0.0005291674,0.0003127637,0.000201624,0.0003200971,0.0004696437,0.0003395354,0.0002007037,0.001294987,0.0004137803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006428653,"about_ca_system_score_gemma":0.0003820338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005435601,"about_ca_topic_score_gemma":0.0007600185,"domain_scores_codex":[0.9994121,0.0001190143,0.00004234505,0.0001233158,0.0001932454,0.0001100932],"domain_scores_gemma":[0.9994844,0.0002112301,0.0001142535,0.00005987428,0.00004613674,0.00008405431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004320545,0.00002058242,0.00002680115,0.00001163234,0.000002057,0.00000594962,0.000004959696,0.00003536959,0.9994066,0.0000611415,0.000008346511,0.0003732997],"study_design_scores_gemma":[0.0000106791,0.0002675462,0.0003601949,0.000001844935,0.000006180974,0.00006946855,0.000003268209,0.0004049268,0.9984136,0.0000257437,0.0004342267,0.000002293528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562917,0.002367618,0.03754975,0.0001661118,0.00005247266,0.0001026179,0.0003376039,0.0003674415,0.002764654],"genre_scores_gemma":[0.9635743,0.001041847,0.03086878,0.0001135509,0.00002482658,0.0001584081,0.001264448,0.00006449073,0.002889388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412308,"threshold_uncertainty_score":0.004724622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160242117634733,"score_gpt":0.2468651584441416,"score_spread":0.2352627372677943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}