{"id":"W2077381882","doi":"10.1016/j.matbio.2013.07.006","title":"Cutis laxa: Intersection of elastic fiber biogenesis, TGFβ signaling, the secretory pathway and metabolism","year":2013,"lang":"en","type":"review","venue":"Matrix Biology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Elastin; Cell biology; Fibulin; Golgi apparatus; Rab; Chemistry; Integrin; Biochemistry; Biology; Receptor; Extracellular matrix; GTPase; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004776822,0.0008316499,0.001387384,0.002050209,0.00029387,0.001194783,0.0007871531,0.001052627,0.002562684],"category_scores_gemma":[0.0004559298,0.0002560228,0.0003361265,0.001877188,0.0005830461,0.001260697,0.0007300872,0.00175355,0.001423288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006500522,"about_ca_system_score_gemma":0.00113034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010594,"about_ca_topic_score_gemma":0.002277183,"domain_scores_codex":[0.9998407,0.00001662163,0.00002303015,0.00002885869,0.00007254355,0.00001814945],"domain_scores_gemma":[0.9997632,0.00008760589,0.00004736731,0.000006774125,0.00006194021,0.00003319115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001041887,0.00005258675,0.0002258632,0.01209011,0.00007939809,0.0004115585,0.00002985034,0.0002800806,0.004416122,0.003516276,0.02328864,0.9555054],"study_design_scores_gemma":[0.00002197786,0.00005536288,0.001048125,0.002305351,0.000119027,0.002382619,0.00006319131,0.0000995694,0.001178093,0.001876596,0.9908282,0.00002188453],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001103241,0.9987653,0.0001725725,0.0002431027,0.0001461937,0.000002481469,0.00001476891,0.00000780373,0.0005374362],"genre_scores_gemma":[0.0006493675,0.9983293,0.0002457454,0.0001383119,0.0001442462,0.000003608693,0.0000247525,0.000001244814,0.0004634047],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002562684,"threshold_uncertainty_score":0.008572996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02827920629674031,"score_gpt":0.3361892081893839,"score_spread":0.3079100018926436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}