{"id":"W2077420696","doi":"10.1073/pnas.0702374104","title":"The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in <i>Drosophila</i>","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Smoothened; Hedgehog; Cell biology; Signal transduction; G protein-coupled receptor; Biology; Transmembrane protein; Hedgehog signaling pathway; G protein-coupled receptor kinase; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001253705,0.0004704355,0.0001826772,0.0002620441,0.0002808063,0.0003819255,0.0001925006,0.0003474039,0.0007436409],"category_scores_gemma":[0.00009318156,0.0002394742,0.0002423666,0.0001170203,0.0002352439,0.0002622376,0.0003066878,0.0003401275,0.0006268881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004096093,"about_ca_system_score_gemma":0.0001339112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008015896,"about_ca_topic_score_gemma":0.0009539743,"domain_scores_codex":[0.999896,0.00001483293,0.000007069281,0.00002817516,0.00002743733,0.00002650132],"domain_scores_gemma":[0.9999707,0.000002770838,0.000007823954,0.000003949091,0.000003675643,0.00001103041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009410456,0.000007461907,0.0003957195,0.00002967928,0.000004290586,0.0001085078,0.000007105848,0.00005648436,0.9980058,0.0001612629,0.0001035286,0.001026069],"study_design_scores_gemma":[0.00005969819,0.0001985044,0.05379898,0.00001593639,0.00004361632,0.001702801,0.00005875389,0.002089212,0.9298704,0.0002814812,0.01186312,0.00001752194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840062,0.006239194,0.003945392,0.0003758479,0.00006385516,0.00002985212,0.0006981502,0.0001790822,0.004462391],"genre_scores_gemma":[0.9913931,0.001781718,0.002140305,0.0001355989,0.00001796077,0.00001774279,0.001033097,0.00002549621,0.003454981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008015896,"threshold_uncertainty_score":0.002971888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03474658077773296,"score_gpt":0.2998134224409848,"score_spread":0.2650668416632518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}