{"id":"W2077420862","doi":"10.1016/j.ajpath.2011.02.015","title":"Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes","year":2011,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Diabetesforbundet; Fondation pour la Recherche Médicale; National Health and Medical Research Council; Alberta Heritage Foundation for Medical Research; Canadian Institutes of Health Research; Australian Diabetes Society; Diabetes Australia; Juvenile Diabetes Research Foundation International","keywords":"Cytotoxic T cell; Pancreatic islets; Biology; NOD mice; CTL*; Granzyme B; Immunology; Granzyme; Islet; Immune system; CD8; Endocrinology; Perforin; Autoimmunity; In vitro; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004160291,0.0001457371,0.000439701,0.0001378217,0.00001279825,0.000003303189,0.0002177613,0.0001001612,0.00001773733],"category_scores_gemma":[0.0001071798,0.0001044051,0.0001505116,0.0001758674,0.0003095463,0.00001046889,0.00005198507,0.00009647002,7.236893e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004169234,"about_ca_system_score_gemma":0.0001066118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005284427,"about_ca_topic_score_gemma":0.000002744456,"domain_scores_codex":[0.9986403,0.0004074,0.0004293882,0.000163371,0.0001244092,0.0002351495],"domain_scores_gemma":[0.9989805,0.00009339409,0.0006393092,0.0001767315,0.00007125611,0.00003887391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007226389,0.0002365614,0.1968146,0.00002496083,0.00004627602,0.00008669163,0.0008156339,0.00000524675,0.799575,0.000002031001,0.000007680005,0.001662763],"study_design_scores_gemma":[0.00118181,0.0009520533,0.6895322,0.0001723909,0.00005003878,0.00005943355,0.001481803,0.00000475228,0.3064285,0.00002570985,0.000009047355,0.0001023671],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988,0.0007200265,0.00003302739,0.00002080573,0.00004925702,0.0001099333,0.00001026744,0.000001310425,0.00025542],"genre_scores_gemma":[0.9988152,0.0001468836,0.0007885071,0.0001792477,0.00002761348,0.00001489632,0.000004116113,0.00001600958,0.000007570554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4931465,"threshold_uncertainty_score":0.4257518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006628823853382908,"score_gpt":0.225628647532267,"score_spread":0.2189998236788841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}