{"id":"W2077420862","doi":"10.1016/j.ajpath.2011.02.015","title":"Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes","year":2011,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Diabetesforbundet; Fondation pour la Recherche Médicale; National Health and Medical Research Council; Alberta Heritage Foundation for Medical Research; Canadian Institutes of Health Research; Australian Diabetes Society; Diabetes Australia; Juvenile Diabetes Research Foundation International","keywords":"Cytotoxic T cell; Pancreatic islets; Biology; NOD mice; CTL*; Granzyme B; Immunology; Granzyme; Islet; Immune system; CD8; Endocrinology; Perforin; Autoimmunity; In vitro; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172901,0.0004776917,0.0004432092,0.0004190535,0.0002369712,0.0006137851,0.0001902701,0.0004292608,0.002599852],"category_scores_gemma":[0.0002661775,0.000319961,0.0002887496,0.0002123001,0.0002773595,0.0005671714,0.0003258776,0.001822153,0.0007608751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317534,"about_ca_system_score_gemma":0.0001377911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001477759,"about_ca_topic_score_gemma":0.0001820369,"domain_scores_codex":[0.9997973,0.00001806603,0.00001548589,0.00006053415,0.00003181358,0.00007683854],"domain_scores_gemma":[0.9996575,0.00004573265,0.0000767024,0.00006358889,0.00002630271,0.0001300666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004696397,0.00004728661,0.0006123341,0.00002432609,0.000002849643,0.00011816,0.00004369653,0.00003325738,0.9978523,0.00008168454,0.00002250054,0.0006920121],"study_design_scores_gemma":[0.00009106855,0.0008555833,0.03029461,0.00002242515,0.00005745599,0.001204708,0.0003296388,0.0005548144,0.9647356,0.000320502,0.001514384,0.00001911136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975569,0.000492991,0.0005236962,0.00004351312,0.00002655724,0.000007965629,0.0001537075,0.00005916525,0.001135501],"genre_scores_gemma":[0.9956684,0.0003845794,0.0004713502,0.00007398176,0.00002251441,0.00002931178,0.0003147931,0.00005005952,0.00298504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002599852,"threshold_uncertainty_score":0.008697391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006628823853382908,"score_gpt":0.225628647532267,"score_spread":0.2189998236788841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}