{"id":"W2077424157","doi":"10.1371/journal.ppat.1003416","title":"Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-Luc; Montreal Clinical Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Canadian Liver Foundation","keywords":"Innate immune system; Biology; Wnt signaling pathway; MDA5; RIG-I; RNA interference; Gene knockdown; Sendai virus; Cell biology; Signal transduction; IRF3; Interferon; Effector; Gene silencing; Intrinsic immunity; Immune system; Gene; Virus; Virology; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225478,0.0004914447,0.0003797438,0.0003413692,0.0001823856,0.0003404431,0.0002234617,0.0002730711,0.001125404],"category_scores_gemma":[0.00009788103,0.000200513,0.000281136,0.0001881299,0.0001810906,0.0001275524,0.0001895843,0.0004353059,0.0003964856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003722003,"about_ca_system_score_gemma":0.000214554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00077957,"about_ca_topic_score_gemma":0.002171749,"domain_scores_codex":[0.9998983,0.00001021955,0.00001149653,0.00003155249,0.00003516335,0.00001327985],"domain_scores_gemma":[0.9999182,0.00001373908,0.00002842031,0.000008634868,0.000009843645,0.00002112473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003046069,0.000004426882,0.000209519,0.00001924728,0.000004336475,0.0000534457,0.000003316549,0.00002889378,0.9990022,0.00004132335,0.00002209948,0.0005807501],"study_design_scores_gemma":[0.00002391785,0.00007578393,0.01881002,0.00001335988,0.00007930099,0.0006968472,0.0000227064,0.002251304,0.9735214,0.00009961401,0.004395543,0.00001018975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756075,0.00469361,0.01353012,0.0002889055,0.00004593463,0.00007878077,0.002620308,0.0003873094,0.002747539],"genre_scores_gemma":[0.982476,0.002346232,0.007139754,0.0001873857,0.000009693138,0.00005947327,0.003759372,0.0000939539,0.003928151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125404,"threshold_uncertainty_score":0.003764808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788822732621751,"score_gpt":0.2316029866115311,"score_spread":0.2137147592853136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}